Brent J. Ryan

University of Oxford — United Kingdom

Medicine · Health Sciences

29h-index3.4kcitations51works2.22yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Parkinson's Disease Mechanisms and Treatments(21), Autophagy in Disease and Therapy(13), Alzheimer's disease research and treatments(8), Genetic Neurodegenerative Diseases(8), Mitochondrial Function and Pathology(6)

Publications51 total

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons
npj Parkinson s Disease·2025Open Access
TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons
2025Open Access
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling
Nature Structural & Molecular Biology·2025· 6 citedOpen Access
USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms
2025· 1 citedOpen Access
M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress
2024· 1 citedOpen Access
CRISPRi: a way to integrate iPSC-derived neuronal models
Biochemical Society Transactions·2024· 5 citedOpen Access
Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Molecular Neurodegeneration·2023· 5 citedOpen Access
Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications
2023· 2 citedOpen Access
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Molecular Neurodegeneration·2023· 36 citedOpen Access
Mitochondrial dysfunction and mitophagy defects in <i>LRRK2-R1441C</i> Parkinson’s disease models
Human Molecular Genetics·2023· 48 citedOpen Access
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
Cell Reports·2023· 33 citedOpen Access
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons
2023· 9 citedOpen Access
Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid
Brain Communications·2022· 33 citedOpen Access
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function
Autophagy·2022· 18 citedOpen Access
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function
Figshare·2022Open Access
Identification of a novel proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF
2021· 3 citedOpen Access
A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease <i>GBA-N370S</i> dopamine neurons
2021· 2 citedOpen Access
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism
Stem Cell Reports·2021· 44 citedOpen Access
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
Frontiers in Cellular Neuroscience·2021· 27 citedOpen Access
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model
Journal of Neuroscience·2021· 35 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Richard Wade‐Martins(33), Helle Bogetofte(8), Sally A. Cowley(8), Paul G. Winyard(8), Jane Vowles(6), Morten Meyer(6), William McGuinness(6), Rachel Heon‐Roberts(6), Stewart W. Humble(6), Ana Belén Malpartida(5), Hugo J. R. Fernandes(5), Joshua Shulman(5), Sissel Ida Schmidt(5), Keith M. Channon(5), Mark J. Crabtree(5), Matthew G Williamson(4), Samuel Evetts(4), Phillippa J. Carling(4), Paul Eggleton(4), Ahuva Nissim(4)