Nicholas Muzyczka

University of Florida — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

81h-index22.7kcitations181works0.02yr avg
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Research Topics

Virus-based gene therapy research(132), Viral Infectious Diseases and Gene Expression in Insects(40), RNA Interference and Gene Delivery(39), Herpesvirus Infections and Treatments(29), CRISPR and Genetic Engineering(22)

Publications181 total

Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants
Journal of Virology·2023· 13 citedOpen Access
Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo
UNC Libraries·2020· 2 citedOpen Access
Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?
UNC Libraries·2020Open Access
Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding
Virus Research·2019· 15 citedOpen Access
The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson’s Disease
Neuroscience·2018· 14 cited
AAV: An Overview of Unanswered Questions
Human Gene Therapy·2017· 108 citedOpen Access
Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging
Journal of Virology·2016· 48 citedOpen Access
Structural Rearrangements in R432A Variant of AAV2 Affect Genome Packaging
Microscopy and Microanalysis·2016Open Access
Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids
Journal of Virology·2016· 37 citedOpen Access
95. Incorporation of AAV Serotype 2 Viral Protein 2 into Other AAV Serotype Capsids
Molecular Therapy·2016Open Access
Structure of the R432A variant of Adeno-associated virus type 2 VLP
2016
Structure of Adeno-associated virus type 2 VLP
2016
Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?
Human Gene Therapy·2015· 77 citedOpen Access
162. Crossing the Blood-Cerebrospinal Fluid Barrier in the Mouse Choroid Plexus With an Engineered Receptor/Ligand System
Molecular Therapy·2015· 1 citedOpen Access
AAV's Golden Jubilee
Molecular Therapy·2015· 18 citedOpen Access
Transcytosis in the blood–cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system
Molecular Therapy — Methods & Clinical Development·2015· 12 citedOpen Access
Adeno-Associated Virus Serotype 1 (AAV1)- and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity
Journal of Virology·2014· 70 citedOpen Access
Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines <i>In Vitro</i> and in Murine Hepatocytes <i>In Vivo</i>
Journal of Virology·2014· 42 citedOpen Access
AAV-Mediated Gene Therapy for Research and Therapeutic Purposes
Annual Review of Virology·2014· 565 citedOpen Access
Overcoming the Cystic Fibrosis Sputum Barrier to Leading Adeno-associated Virus Gene Therapy Vectors
Molecular Therapy·2014· 88 citedOpen Access
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Frequent Co-authors

Sergei Zolotukhin(15), Ronald J. Mandel(10), Mavis Agbandje‐McKenna(9), Corinna Bürger(8), Barry J. Byrne(7), R. Jude Samulski(7), Oleg S. Gorbatyuk(6), Deniz Kirik(6), Irene Zolotukhin(5), Terence R. Flotte(5), Richard O. Snyder(5), Mark Potter(4), Anders Björklund(4), William W. Hauswirth(4), Kenneth I. Berns(4), Robert McKenna(4), Dong‐Soon Im(4), L. Govindasamy(3), Kenneth H. Warrington(3), Arun Srivastava(3)