Deniz Kirik

University of Sydney — Australia

Medicine · Health Sciences

70h-index19.5kcitations236works1.42yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(103), Nerve injury and regeneration(91), Neurological disorders and treatments(61), Genetic Neurodegenerative Diseases(36), Virus-based gene therapy research(30)

Publications236 total

GEMSTONE Research Data: Alpha-Synuclein IHC Images and Protocols
Zenodo (CERN European Organization for Nuclear Research)·2025Open Access
GEMSTONE Research Data: Alpha-Synuclein IHC Images and Protocols
Zenodo (CERN European Organization for Nuclear Research)·2025Open Access
Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice
Acta Neuropathologica Communications·2025Open Access
PARKIN protein-deficient iPSC line (FINi006-A) from an early-onset Parkinson’s disease female patient
Stem Cell Research·2025· 1 citedOpen Access
Dopamine and cortical neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction
npj Parkinson s Disease·2025· 3 citedOpen Access
TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice
Acta Neuropathologica Communications·2025· 4 citedOpen Access
Using SILMAS to improve machine learning-assisted quantification of pathology
Optics Letters·2025Open Access
Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
2025Open Access
Zero-length crosslinking: A breakthrough approach for evaluating target engagement in α-synuclein immunotherapy
Journal of Pharmacology and Experimental Therapeutics·2024· 1 cited
Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain
npj Parkinson s Disease·2024· 5 citedOpen Access
Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell loss
2024· 1 citedOpen Access
State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons
Biology·2024· 6 citedOpen Access
A040 The role of metabolic hypothalamic circuitries in Huntington’s disease
2024Open Access
A039 Effects of mutant huntingtin and TDP-43 in the hypothalamus on the development of neuropathology and metabolic dysregulation
2024Open Access
Image post-processing for SILMAS: structured illumination light sheet microscopy with axial sweeping
Biomedical Optics Express·2024· 2 citedOpen Access
Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain
2024Open Access
Basal activity of PINK1 and PRKN in cell models and rodent brain
Autophagy·2023· 24 citedOpen Access
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease
Scientific Reports·2023· 13 citedOpen Access
Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene
Stem Cell Research·2023· 5 citedOpen Access
Robust nuclease-dead S. aureus dCas9-mediated alpha-synuclein knockdown in substantia nigra in a humanized mouse model of Parkinson’s disease
2023· 5 citedOpen Access
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Frequent Co-authors

Anders Björklund(31), Carl Rosenblad(14), Biljana Georgievska(10), Christian Winkler(8), Cecilia Lundberg(8), Ronald J. Mandel(8), Corinna Bürger(6), Nicholas Muzyczka(6), Thomas Carlsson(6), Manolo Carta(5), Lachlan H. Thompson(4), Marina Romero‐Ramos(4), M. Angela Cenci(3), Teit E. Johansen(3), Tomas Björklund(3), Ayşe Ulusoy(3), Martin Lundblad(2), Lucy E. Annett(2), Barbara Moffat(2), Heidi Phillips(2)