Sundeep Malik

University of Rochester Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.0kcitations53works1.72yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(23), Ion channel regulation and function(18), Receptor Mechanisms and Signaling(14), Ion Channels and Receptors(9), Neurobiology and Insect Physiology Research(8)

Publications53 total

Expanding the Early Childhood Manifestations of <i>ITPR1</i> Heterozygous Variants Beyond Congenital Ataxia and Gillespie Syndrome
Neurology Genetics·2025Open Access
Voluntary Wheel Running Mitigates Disease in an Orai1 Gain-of-Function Mouse Model of Tubular Aggregate Myopathy
Cells·2025Open Access
Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity
Journal of Biological Chemistry·2025· 2 citedOpen Access
Compound heterozygous <scp>RYR1</scp> ‐ <scp>RM</scp> mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival
The FASEB Journal·2024· 4 citedOpen Access
An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease
The EMBO Journal·2024· 3 citedOpen Access
Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity
2024· 1 citedOpen Access
Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy
2023· 2 citedOpen Access
Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
eLife·2023· 26 citedOpen Access
Characterization of ORAI1G100s/+ mouse model of tubular aggregate myopathy
Biophysical Journal·2023Open Access
Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca2+ channels and activation of store-operated Ca2+ entry
iScience·2022· 13 citedOpen Access
Author response: Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
2022Open Access
Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors
Proceedings of the National Academy of Sciences·2022· 37 citedOpen Access
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy
The Journal of General Physiology·2022· 17 citedOpen Access
Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup>
2022Open Access
Missense Mutations in Inositol 1,4,5-Trisphosphate Receptor Type 3 Result in Leaky Ca &lt;sup&gt;2+&lt;/sup&gt; Channels and Inappropriate Activation of Store-Operated Ca &lt;sup&gt;2+&lt;/sup&gt; Entry
SSRN Electronic Journal·2022Open Access
CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors
Journal of Cell Science·2021· 14 citedOpen Access
Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function
Journal of Biological Chemistry·2020· 22 citedOpen Access
Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle
eLife·2019· 49 citedOpen Access
Author response: Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle
2019Open Access
Mouse model of severe recessive RYR1-related myopathy
Human Molecular Genetics·2019· 41 citedOpen Access
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Frequent Co-authors

Alan V. Smrcka(23), David I. Yule(13), Robert T. Dirksen(11), Vikas Arige(8), Grant G. Kelley(6), Antonio Michelucci(6), Laura Pietrangelo(6), Feliciano Protasi(6), Lara E. Terry(6), Jay Yang(5), Linda Groom(5), Lianghui Zhang(4), Simona Boncompagni(4), Maricela García‐Castañeda(4), Larry E. Wagner(4), Thomas N. O’Connor(4), Tabetha M. Bonacci(3), Emily A. Oestreich(3), Burns C. Blaxall(3), Mousumi Ghosh(3)