Grant G. Kelley

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

23h-index2.7kcitations45works0.02yr avg
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Research Topics

Pancreatic function and diabetes(15), Protein Kinase Regulation and GTPase Signaling(12), Metabolism, Diabetes, and Cancer(10), Receptor Mechanisms and Signaling(8), Diabetes and associated disorders(6)

Publications45 total

Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits
UNC Libraries·2021Open Access
Beta Cell CICR Model
2015
INS-1 Epac1 camps Clone10
2015
Epac2 KO Characterization
2015
INS1 Clone 10 Epac1 camps
2015
J Physiol 2010 Islam Perspective
2012
Phospholipase C∈ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes
Journal of Biological Chemistry·2011· 100 citedOpen Access
Phospholipase C-Epsilon Couples cAMP Production and Epac2 Activation to the Facilitation of Calcium-Induced Calcium Release (CICR) in Pancreatic Beta Cells
Biophysical Journal·2011Open Access
Epac2-dependent mobilization of intracellular Ca<sup>2+</sup>by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice
The Journal of Physiology·2010· 69 citedOpen Access
A Permissive Role for Protein Kinase a in Support of Epac Agonist-Stimulated Human Islet Insulin Secretion
Biophysical Journal·2010Open Access
J Physiol Perspective Regarding Dzhura et al. 2010
2010
PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-<i>O</i>-Me-cAMP-AM in human islets of Langerhans
American Journal of Physiology-Endocrinology and Metabolism·2009· 79 cited
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2’-O-Me-cAMP-AM
Islets·2009· 36 citedOpen Access
Enhanced Rap1 Activation and Insulin Secretagogue Properties of an Acetoxymethyl Ester of an Epac-selective Cyclic AMP Analog in Rat INS-1 Cells
Journal of Biological Chemistry·2009· 61 citedOpen Access
Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II
Journal of Biological Chemistry·2008· 203 citedOpen Access
Phospholipase Cδ1 regulates cell proliferation and cell-cycle progression from G1- to S-phase by control of cyclin E–CDK2 activity
Biochemical Journal·2008· 19 cited
PLCε Selectively Transduces Thrombin Versus LPA Signals to Astrocyte Proliferation Through Rap1 and Rho
The FASEB Journal·2008
Phospholipase Cε is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
Proceedings of the National Academy of Sciences·2007· 74 citedOpen Access
SPFH2 Mediates the Endoplasmic Reticulum-associated Degradation of Inositol 1,4,5-Trisphosphate Receptors and Other Substrates in Mammalian Cells
Journal of Biological Chemistry·2007· 108 citedOpen Access
Epac-mediated Activation of Phospholipase Cɛ Plays a Critical Role in β-Adrenergic Receptor-dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes
Journal of Biological Chemistry·2006· 182 citedOpen Access
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Frequent Co-authors

Alan V. Smrcka(14), Oleg G. Chepurny(12), Igor Dzhura(10), Colin A. Leech(10), George G. Holz(10), Elvira Dzhura(9), Michael W. Roe(7), Xiangquan Li(7), Michael J. Rindler(7), W. S. Zawalich(7), Sundeep Malik(6), Frank Schwede(6), Hans‐Gottfried Genieser(6), Kathleen C. Zawalich(6), Sarah E. Reks(5), Parisa Jalilzadeh Afshari(5), Emily A. Oestreich(4), Channing J. Der(4), Burns C. Blaxall(3), Robert T. Dirksen(3)