Walther Mothes

Yale University — United States

Immunology and Microbiology · Life Sciences

56h-index15.1kcitations195works5.82yr avg
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Research Topics

HIV Research and Treatment(84), SARS-CoV-2 and COVID-19 Research(42), HIV/AIDS drug development and treatment(27), Immune Cell Function and Interaction(25), Monoclonal and Polyclonal Antibodies Research(22)

Publications195 total

Viral glycoprotein-mediated entry and antibody-mediated immunity in HIV-1 and SARS-CoV-2 infection
Frontiers in Immunology·2026Open Access
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
Nature Communications·2025· 1 citedOpen Access
HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors
UNC Libraries·2025Open Access
HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors
Nature Communications·2025· 2 citedOpen Access
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
Nature·2025· 4 citedOpen Access
Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
Nature·2025Open Access
HKU5 bat merbecoviruses use divergent mechanisms to engage bat and mink ACE2 as entry receptors
2025· 4 citedOpen Access
BPS2025 - Structure and inhibition of SARS-CoV-2 spike refolding in membranes
Biophysical Journal·2025
Correction for Kajaste-Rudnitski et al., “TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-κB-Responsive Long Terminal Repeat Elements”
Journal of Virology·2025· 1 citedOpen Access
Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered conformation
Journal of Virology·2024· 2 citedOpen Access
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
2024· 1 citedOpen Access
The KT Jeang retrovirology prize 2024: Walther Mothes
Retrovirology·2024Open Access
Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice
Vaccines·2024· 2 citedOpen Access
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
2024· 3 citedOpen Access
Structure and inhibition of SARS-CoV-2 spike refolding in membranes
Science·2024· 44 citedOpen Access
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation
Cell Reports·2024· 8 citedOpen Access
Beta Spike-Presenting SARS-CoV-2 Virus-Like Particle Vaccine Confers Broad Protection against Other VOCs in Mice
Preprints.org·2024· 2 citedOpen Access
Proof-of-concept studies with a computationally designed M<sup>pro</sup>inhibitor as a synergistic combination regimen alternative to Paxlovid
Proceedings of the National Academy of Sciences·2024· 15 citedOpen Access
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors
Science Advances·2024· 16 citedOpen Access
Viral spike-receptor interactions monitored by cryo-electron tomograpy on membranes
Biophysical Journal·2024Open Access
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Frequent Co-authors

Pradeep D. Uchil(16), James B. Munro(10), Scott C. Blanchard(10), Peter D. Kwong(9), Jason Gorman(8), Maolin Lu(8), Andrés Finzi(8), Tongqing Zhou(7), Xiaochu Ma(7), Nathan M. Sherer(7), Tom A. Rapoport(6), Daniel S. Terry(6), Shilei Ding(6), Jérémie Prévost(6), Baoshan Zhang(5), Amos B. Smith(5), Luis M. Agosto(5), Romain Gasser(5), Jonathan Richard(5), Joseph Sodroski(5)