John Troutman

Procter & Gamble (United States) — United States

Medicine · Health Sciences

15h-index987citations30works4.02yr avg
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Research Topics

Contact Dermatitis and Allergies(11), Effects and risks of endocrine disrupting chemicals(8), Animal testing and alternatives(7), Plant Toxicity and Pharmacological Properties(6), Advancements in Transdermal Drug Delivery(5)

Publications30 total

Toxins in Botanical Drugs and Plant-derived Food and Feed – from Science to Regulation: A Workshop Review
Planta Medica·2024· 4 citedOpen Access
Enhancement of Skin Permeability Prediction through PBPK Modeling, Bayesian Inference, and Experiment Design
Pharmaceutics·2023· 2 citedOpen Access
Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application
Journal of Pharmaceutical Sciences·2023· 14 citedOpen Access
Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment
Regulatory Toxicology and Pharmacology·2022· 16 citedOpen Access
A Mechanistic Bayesian Inferential Workflow for Estimation of In Vivo Skin Permeation from In Vitro Measurements
Journal of Pharmaceutical Sciences·2021· 12 cited
Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment–A Workshop Report
Planta Medica·2021· 19 citedOpen Access
Including the intestinal microbiome incubations in physiologically based kinetic modeling of pyrrolizidine alkaloid N-oxides
Toxicology Letters·2021Open Access
Cosmetics Europe evaluation of 6 in silico skin penetration models
Computational Toxicology·2021· 33 citedOpen Access
Assessment of Vehicle Volatility and Deposition Layer Thickness in Skin Penetration Models
Pharmaceutics·2021· 15 citedOpen Access
Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma
Regulatory Toxicology and Pharmacology·2021· 20 cited
Refinement of the Peroxidase Peptide Reactivity Assay and Prediction Model for Assessing Skin Sensitization Potential
Toxicological Sciences·2020· 12 citedOpen Access
P169 - Pyrrolizidine alkaloid DNA adduct formation and the interplay between uptake, metabolism, and efflux in rat sandwich cultured hepatocytes
Drug Metabolism and Pharmacokinetics·2020
Predicting the pharmacokinetics of piperacillin and tazobactam in preterm and term neonates using physiologically based pharmacokinetic modeling
Computational Toxicology·2019· 5 cited
Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism
Food and Chemical Toxicology·2019· 28 cited
Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model
Computational Toxicology·2019· 10 citedOpen Access
In vitro assessment of the relative toxicity of a series of pyrrolizidine alkaloids: Taking account of metabolic activation and toxicokinetics
Drug Metabolism and Pharmacokinetics·2019
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making
Computational Toxicology·2018· 135 citedOpen Access
Cosmetic Europe's long range science strategy – A non-animal safety assessment case study for phenoxyethanol, a cosmetic ingredient
Toxicology Letters·2018
Development of growth equations from longitudinal studies of body weight and height in the full term and preterm neonate: From birth to four years postnatal age
Birth Defects Research·2018· 19 citedOpen Access
EURL ECVAM WORKSHOP ON NEW GENERATION OF PHYSIOLOGICALLY-BASED KINETIC MODELS IN RISK ASSESSMENT
Liverpool John Moores University·2017· 14 citedOpen Access
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Frequent Co-authors

Catherine Mahony(8), G. Frank Gerberick(6), Cindy Obringer(5), Carsten Goebel(4), Jeffrey W. Fisher(4), Cathy Lester(4), Abdullah Hamadeh(4), Andrea N. Edginton(4), Annie Lumen(3), Alicia Paini(3), Mike Quijano(3), Roy L. M. Dobson(3), Martina Klarić(3), Ans Punt(3), Helga Rothe(3), Abdulkarim Najjar(3), Andreas Schepky(3), Nicola J. Hewitt(3), Leslie M. Foertsch(2), Jean‐Pierre Lepoittevin(2)