Cathy Lester

Chemistry · Physical Sciences

25h-index1.6kcitations49works0.02yr avg
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Research Topics

Advanced NMR Techniques and Applications(11), Computational Drug Discovery Methods(10), Effects and risks of endocrine disrupting chemicals(9), Animal testing and alternatives(8), Pesticide Exposure and Toxicity(7)

Publications49 total

A case study with benzoic acid demonstrating how integration of In Silico Tools, mechanistic In Vitro NAM, and toxicological data improves definition of point of departure for a chemically defined class in read-across assessments
NAM journal.·2026
Investigations into the biological activity of avobenzone as part of a Next Generation Risk Assessment
NAM journal.·2025Open Access
Utilizing metabolism-based structure-activity relationships and biokinetic modeling for toxicological evaluation: A case study on L-menthyl D-Lactate
Regulatory Toxicology and Pharmacology·2025
The role of a molecular informatics platform to support next generation risk assessment
Computational Toxicology·2023· 14 citedOpen Access
Quantifying Analogue Suitability for SAR-Based Read-Across Toxicological Assessment
Chemical Research in Toxicology·2023· 28 citedOpen Access
Impact of chemical structure on the in vitro hydrolysis of fatty esters of 2-ethylhexanoic acid or 2-ethylhexanol and extrapolation to the in vivo situation
Regulatory Toxicology and Pharmacology·2022· 4 cited
Letter to the editor
Toxicological Sciences·2022
A New Approach Methodology (NAM) Based Assessment of Butylated hydroxytoluene (BHT) for Endocrine Disruption Potential
Toxicological Sciences·2022· 11 citedOpen Access
Assessing the genotoxicity and carcinogenicity of 2-chloroethanol through structure activity relationships and in vitro testing approaches
Food and Chemical Toxicology·2022· 12 citedOpen Access
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens
Regulatory Toxicology and Pharmacology·2022· 46 citedOpen Access
A matched molecular pair (MMP) approach for selecting analogs suitable for structure activity relationship (SAR)-based read across
Regulatory Toxicology and Pharmacology·2021· 30 cited
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine
Regulatory Toxicology and Pharmacology·2021· 48 citedOpen Access
Effect of chain length and branching on the in vitro metabolism of a series of parabens in human liver S9, human skin S9, and human plasma
Regulatory Toxicology and Pharmacology·2021· 20 cited
Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models
Toxicology in Vitro·2020· 16 citedOpen Access
P169 - Pyrrolizidine alkaloid DNA adduct formation and the interplay between uptake, metabolism, and efflux in rat sandwich cultured hepatocytes
Drug Metabolism and Pharmacokinetics·2020
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol
Journal of Applied Toxicology·2019· 66 citedOpen Access
Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism
Food and Chemical Toxicology·2019· 28 cited
Use of connectivity mapping to support read across: A deeper dive using data from 186 chemicals, 19 cell lines and 2 case studies
Toxicology·2019· 42 cited
In vitro assessment of the relative toxicity of a series of pyrrolizidine alkaloids: Taking account of metabolic activation and toxicokinetics
Drug Metabolism and Pharmacokinetics·2019
Evaluation of 6 in silico skin penetration models to predict the in vitro cutaneous distribution of 25 chemicals
Toxicology Letters·2018
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Frequent Co-authors

Catherine Mahony(9), Robert G. Bryant(8), Nicola J. Hewitt(8), Jorge M. Naciff(7), Corie A. Ellison(7), Harold A. Scheraga(6), Cindy Obringer(6), Shengde Wu(5), George P. Daston(5), Andreas Schepky(5), Karen Blackburn(4), Martina Klarić(4), John Troutman(4), Michael C. Laufersweiler(3), Sebastien Grégoire(3), Carine Jacques(3), Ian Sorrell(3), Daniela Lange(3), M Cronin(3), Ann Detroyer(3)