Tal Keren‐Kaplan

AstraZeneca (Netherlands) — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.3kcitations21works4.52yr avg
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Research Topics

Cellular transport and secretion(10), Ubiquitin and proteasome pathways(8), Calcium signaling and nucleotide metabolism(7), Autophagy in Disease and Therapy(4), Glycosylation and Glycoproteins Research(3)

Publications21 total

Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in <i>Staphylococcus aureus</i> Infection
The Journal of Infectious Diseases·2025· 1 citedOpen Access
ARMH3 is an ARL5 effector that promotes PI4KB-catalyzed PI4P synthesis at the trans-Golgi network
Nature Communications·2024· 8 citedOpen Access
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
Cell Reports·2023· 47 citedOpen Access
PI4P and BLOC-1 remodel endosomal membranes into tubules
The Journal of Cell Biology·2022· 29 citedOpen Access
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
Nature Communications·2022· 72 citedOpen Access
Novel Lysosomal Positioning Defects Due to Biallelic Mutations in BORCS7 Causes a Neurodegenerative Disease Presenting as Hereditary-Spastic Paraplegia
Neuropediatrics·2021
PI4P and BLOC-1 remodel endosomal membranes into tubules
2021· 6 citedOpen Access
RUFY3 and RUFY4 are ARL8 effectors that couple lysosomes to dynein-dynactin
2021· 1 citedOpen Access
ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1
Current Biology·2020· 67 citedOpen Access
Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling
Nature Cell Biology·2019· 105 citedOpen Access
Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10
IntechOpen eBooks·2019Open Access
E. coli-Based Selection and Expression Systems for Discovery, Characterization, and Purification of Ubiquitylated Proteins
Methods in molecular biology·2018· 3 cited
A Ragulator–BORC interaction controls lysosome positioning in response to amino acid availability
The Journal of Cell Biology·2017· 127 citedOpen Access
Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligases
The EMBO Journal·2017· 56 citedOpen Access
Mechanisms and functions of lysosome positioning
Journal of Cell Science·2016· 562 citedOpen Access
Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism
Nature Communications·2016· 43 citedOpen Access
A bacterial genetic selection system for ubiquitylation cascade discovery
Nature Methods·2016· 27 cited
STRUCTURE OF UBIQUITYLATED-RPN10 FROM YEAST;
2016
Structure‐based in silico identification of ubiquitin‐binding domains provides insights into the ALIX‐V:ubiquitin complex and retrovirus budding
The EMBO Journal·2013· 64 citedOpen Access
Purification and crystallization of mono-ubiquitylated ubiquitin receptor Rpn10
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2012· 11 citedOpen Access
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Frequent Co-authors

Juan S. Bonifacino(11), Gali Prag(9), Ilan Attali(8), Olga Levin‐Kravets(7), Jing Pu(3), Yan Li(3), Shay Artzi(3), Inbar Pilzer(3), Neta Tanner(3), Oded Kleifeld(3), Noa Shohat(3), Shay Ben‐Aroya(3), Amra Sarić(2), Chad D. Williamson(2), Avinash K. Persaud(2), Khatereh Motamedchaboki(2), Dieter A Wolf(2), Yael Reshef(2), Michael H. Glickman(2), Ori Zucker(2)