I. McConnell

Beth Israel Deaconess Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index6.5kcitations52works1.02yr avg
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Research Topics

Prion Diseases and Protein Misfolding(41), Trace Elements in Health(22), Neurological diseases and metabolism(12), Viral Infections and Immunology Research(5), RNA regulation and disease(4)

Publications52 total

Overcoming immune imprinting with the COVID-19 LP.8.1 mRNA boosters
The Lancet Infectious Diseases·2026
Immunogenicity of JN.1 and KP.2 COVID-19 mRNA vaccines against emerging SARS-CoV-2 variants
Vaccine·2025· 1 citedOpen Access
Minimise transmission risk of CJD and vCJD in healthcare settings. Report on the Prevention of CJD and vCJD by Advisory Committee on Dangerous Pathogens' Transmission Spongiform Encephalopathy (ACDP TSE) Subgroup.
ePrints Soton (University of Southampton)·2015· 7 citedOpen Access
Transmissions of variant Creutzfeldt–Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice
Journal of General Virology·2009· 72 cited
Scrapie affected mice survive longer with parenteral Pentosan Polysulphate
2008
Sporadic CJD strain classification by transmission to human transgenic mice
Prion·2008
Maedi‐Visna
2007· 8 cited
TSE Strain Typing in Mice
Birkhäuser Basel eBooks·2004· 8 cited
Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility
Journal of Virology·2003· 151 citedOpen Access
Thermostability of mouse-passaged BSE and scrapie is independent of host PrP genotype: implications for the nature of the causal agents
Journal of General Virology·2002· 54 cited
Does pentosan polysulphate have prophylactic potential for transmissible spongiform encephalopathies?
Biochemical Society Transactions·2002
Does pentosan polysulphate have prophylactic potential for transmissible spongiform encephalopathies?
Biochemical Society Transactions·2002
Strain characterization of natural sheep scrapie and comparison with BSE
Journal of General Virology·2002· 209 cited
Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues
The Lancet·2001· 255 cited
Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice
Proceedings of the National Academy of Sciences·2001· 121 citedOpen Access
Closely similar values obtained when the ME7 strain of scrapie agent was titrated in parallel by two individuals in separate laboratories using two sublines of C57BL mice
Journal of Virological Methods·2000· 14 cited
Book review: NAFTA and the Energy Charter Treaty: Compliance with, Implementation and Effectiveness of International Investment Agreements, Miriam Kene Omalu (Kluwer Law International, 1998, 320 pp) £61.25
Utilities Law Review·2000
A single amino acid alteration in murine PrP dramatically alters TSE incubation time
2000· 16 cited
Survival of scrapie agent after exposure to sodium dodecyl sulphate and heat
Veterinary Microbiology·1999· 24 cited
Observations on thermostable subpopulations of the unconventional agents that cause transmissible degenerative encephalopathies
Veterinary Microbiology·1998· 48 cited
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Frequent Co-authors

H. Fraser(15), David Taylor(11), M. E. Bruce(9), Jayne C. Hope(7), K. Fernie(6), Jean Manson(5), Moira E. Bruce(5), James W. Ironside(4), A. Chree(4), A.G. Dickinson(4), Christine Farquhar(4), Patricia McBride(3), Aileen Boyle(3), Philip Steele(3), Linda McCardle(2), Simon Cousens(2), Christopher J. Bostock(2), Alan R. Clarke(2), James D. Foster(2), Karen Brown(2)