Owain W. Howell

Swansea University — United Kingdom

Medicine · Health Sciences

41h-index10.4kcitations89works11.92yr avg
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Research Topics

Multiple Sclerosis Research Studies(44), Neuroinflammation and Neurodegeneration Mechanisms(31), Neurogenesis and neuroplasticity mechanisms(20), Peripheral Neuropathies and Disorders(13), Neuroscience and Neuropharmacology Research(11)

Publications89 total

Spatial transcriptomics of compartmentalised inflammation in a natural disease multiple sclerosis cohort
2025Open Access
Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis
Neurology Neuroimmunology & Neuroinflammation·2025· 4 citedOpen Access
Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis
Brain Pathology·2025· 2 citedOpen Access
Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics
Annals of Neurology·2025· 1 citedOpen Access
Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis
Brain Pathology·2024· 17 citedOpen Access
Issue Information
Annals of Neurology·2024· 1 citedOpen Access
Digital Pathology Identifies Associations between Tissue Inflammatory Biomarkers and Multiple Sclerosis Outcomes
Cells·2024· 1 citedOpen Access
Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis
Annals of Neurology·2024· 69 citedOpen Access
High Levels of Perivascular Inflammation and Active Demyelinating Lesions at Time of Death Associated with Rapidly Progressive Multiple Sclerosis Disease Course: A Retrospective Postmortem Cohort Study
Annals of Neurology·2023· 14 citedOpen Access
Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis
Annals of Neurology·2023· 27 citedOpen Access
Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development
iScience·2023· 8 citedOpen Access
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Nature Communications·2023· 156 citedOpen Access
Meningeal inflammation as a driver of cortical grey matter pathology and clinical progression in multiple sclerosis
Nature Reviews Neurology·2023· 65 cited
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis
Frontiers in Cellular Neuroscience·2023· 16 citedOpen Access
Analysis of target mRNAs in the fixed-frozen human brain using a modified BaseScope-ISH Assay protocol
STAR Protocols·2022· 1 citedOpen Access
A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis
Biomedicines·2022· 23 citedOpen Access
“Ependymal‐in” Gradient of Thalamic Damage in Progressive Multiple Sclerosis
Annals of Neurology·2022· 61 citedOpen Access
A multicentre, open label, single-arm, phase 3b study (CONSONANCE) to assess the effectiveness and safety of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year-1 interim analysis (P1-1.Virtual)
Neurology·2022· 4 cited
A multicenter, open label, single-arm, phase 3b study (CONSONANCE) to assess efficacy of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year 1 interim analysis of cognition outcomes (P1-1.Virtual)
Neurology·2022· 2 cited
The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome
Brain Pathology·2022· 28 citedOpen Access
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Frequent Co-authors

Richard Reynolds(28), Roberta Magliozzi(16), Richard Nicholas(13), Ruth M. McKernan(7), Cyrille Sur(7), John Atack(7), Federico Roncaroli(7), James Neal(6), Paul J. Whiting(5), Barbara Serafini(4), Francesca Aloisi(4), Keith A. Wafford(4), Janice Myers(4), Alison Macaulay(4), Gerard R. Dawson(4), Thomas W. Rosahl(4), Massimiliano Calabrese(4), William Gray(4), B. Paul Morgan(4), Lewis M. Watkins(4)