Thomas W. Rosahl

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Neuroscience · Life Sciences

35h-index7.6kcitations76works1.82yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(27), Alzheimer's disease research and treatments(19), Memory and Neural Mechanisms(10), Cholinesterase and Neurodegenerative Diseases(7), Receptor Mechanisms and Signaling(6)

Publications76 total

A mitochondrial amidoxime-reducing component 1 (mARC1) A168T amino acid substitution does not confer protection from MASH and fibrosis in multiple mouse models of chronic liver disease
Biochemical Journal·2025Open Access
LINE-1 transposition into murine Thyroglobulin results in congenital thyroid dysplasia
PLoS ONE·2025Open Access
Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs
Drug Metabolism and Disposition·2025
Humanized NaV1.8 rats overcome cross-species potency shifts in developing novel NaV1.8 inhibitors
Neurobiology of Pain·2025· 4 citedOpen Access
Loss of mitochondrial amidoxime-reducing component 1 (mARC1) prevents disease progression by reducing fibrosis in multiple mouse models of chronic liver disease
Hepatology Communications·2025· 7 citedOpen Access
Reduction of NLRP3 inflammasome-mediated inflammation in a novel inducible NEK7 knockout mouse model
Journal of Pharmacology and Experimental Therapeutics·2024
Abstract 2455: Development of a bioluminescence reporter mouse model for tracking and quantifying Ly6G+ neutrophils in vivo
Cancer Research·2022
Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice
American Journal of Physiology-Endocrinology and Metabolism·2022· 5 cited
A bioluminescence reporter mouse model for visualizing and quantifying CD8+ T cells in vivo
Neoplasia·2022· 1 citedOpen Access
BACE1 – but not BACE2 – function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice
2021· 1 citedOpen Access
Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy
Frontiers in Immunology·2021· 5 citedOpen Access
High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New “Histo3D” System
Biomedicines·2021· 14 citedOpen Access
Droplet digital PCR or quantitative PCR for in-depth genomic and functional validation of genetically altered rodents
Methods·2021· 27 citedOpen Access
C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxin
2020· 2 citedOpen Access
Corrigendum: Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation
Frontiers in Immunology·2020· 7 citedOpen Access
Abstract 13402: FHL-1 Contributes to and Colocalizes With Titin in Cardiac Hypertrophy
Circulation·2020· 1 cited
Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation
Frontiers in Immunology·2020· 38 citedOpen Access
Antinociceptive effects of potent, selective and brain penetrant muscarinic M4 positive allosteric modulators in rodent pain models
Brain Research·2020· 2 cited
BACE1 partial deletion induces synaptic plasticity deficit in adult mice
Scientific Reports·2019· 29 citedOpen Access
Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects
American Journal of Physiology-Endocrinology and Metabolism·2018· 35 citedOpen Access
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Frequent Co-authors

Keith A. Wafford(13), John Atack(9), Paul J. Whiting(9), Delia Belelli(7), Jeremy J. Lambert(7), Ruth M. McKernan(6), Guy R. Seabrook(6), Gerard R. Dawson(6), David S. Reynolds(6), Mark S. Shearman(6), Gillian F. O’Meara(5), Richard J. Newman(5), Thomas C. Südhof(4), Frederick M. Kuenzi(4), Cyrille Sur(4), Owain W. Howell(4), Alison Macaulay(4), Peter H. Hutson(4), Rosa Fradley(4), Huw D. Lewis(4)