Valerie Hoesch

AstraZeneca (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index173citations11works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Receptor Mechanisms and Signaling(6), Neuroscience and Neuropharmacology Research(4), Pharmacological Receptor Mechanisms and Effects(4), Neuropeptides and Animal Physiology(3), Respiratory viral infections research(2)

Publications11 total

Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling
Tetrahedron Letters·2017· 15 cited
Design and structure–activity relationships of novel inhibitors of human rhinovirus 3C protease
Bioorganic & Medicinal Chemistry Letters·2016· 20 cited
Novel inhibitors of human rhinovirus 3C protease
2016
In vitro binding of a radio‐labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5
Synapse·2012· 1 cited
Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
ACS Medicinal Chemistry Letters·2012· 27 citedOpen Access
4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: Identifying clinical candidates
Bioorganic & Medicinal Chemistry Letters·2011· 10 citedOpen Access
Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications
Bioorganic & Medicinal Chemistry Letters·2011· 6 citedOpen Access
Synthesis of a delta opioid agonist in [<sup>2</sup>H<sub>6</sub>], [<sup>2</sup>H<sub>4</sub>], [<sup>11</sup>C], and [<sup>14</sup>C] labeled forms
Journal of Labelled Compounds and Radiopharmaceuticals·2011· 11 cited
Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
Bioorganic & Medicinal Chemistry Letters·2011· 33 citedOpen Access
Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening
Drug Metabolism and Disposition·2010· 23 cited
4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2010· 27 citedOpen Access

Frequent Co-authors

Megan M. King(5), Nathan Spear(4), Kelly Brush(4), Scott Throner(3), Xia Wang(3), R.A. Gadient(3), Dean G. Brown(3), John P. McCauley(3), Steven S. Wesolowski(3), Charles S. Elmore(3), William E. Palmer(3), Thomas J. Hudzik(3), Cathy L. Dantzman(3), Jeffrey Varnes(2), Linda A. Sygowski(2), James B. Campbell(2), Becky Brockel(2), Vijay Chhajlani(2), Ye Wu(2), Jian Yu(2)