Bart De Strooper

Flemish Community — Belgium

Medicine · Health Sciences

142h-index76.6kcitations678works8.62yr avg
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Research Topics

Alzheimer's disease research and treatments(331), Neuroinflammation and Neurodegeneration Mechanisms(91), Cholinesterase and Neurodegenerative Diseases(66), Computational Drug Discovery Methods(59), Nuclear Receptors and Signaling(51)

Publications676 total

Single-cell phenomics through integrated imaging and molecular profiling
2025Open Access
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
Nature Neuroscience·2025· 2 citedOpen Access
Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo
2025Open Access
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
Journal of Internal Medicine·2025· 1 citedOpen Access
The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation
Science Advances·2025· 1 citedOpen Access
The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease
Molecular Neurodegeneration Advances·2025Open Access
Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency
2025Open Access
The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease
2025Open Access
FAIR sharing of Chromatin Tracing datasets using the newly developed 4DN FISH Omics Format.
PubMed·2025
A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies
eLife·2025Open Access
Author response: A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies
2025Open Access
The Alzheimer’s therapeutic Lecanemab induces an amyloid-clearing program in microglia
2025· 1 citedOpen Access
CTAD taskforce: genetic therapies in Alzheimer’s disease
The Journal of Prevention of Alzheimer s Disease·2025· 3 citedOpen Access
Author Response: A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies
2025Open Access
A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies
2025Open Access
Brain-penetrant anti-C7 therapy reduces neurodegeneration and microgliosis in an Alzheimer’s mouse model
Immunobiology·2025· 1 citedOpen Access
Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer’s Disease
The Journal of Prevention of Alzheimer s Disease·2025Open Access
Microglial response to amyloid-β pathology is modulated by X chromosome dosage
2025Open Access
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease
Nature Communications·2025· 5 citedOpen Access
A proteogenomic tool uncovers protein markers for human microglial states
2025Open Access
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Frequent Co-authors

Paul Säftig(9), Eric Karran(8), Katleen Craessaerts(8), Lutgarde Serneels(7), Wim Annaert(6), Dieter Hartmann(5), Patrik Verstreken(5), Christian Haass(4), Sébastien S. Hébert(4), Iryna Voytyuk(4), Robert Vassar(4), Sven Vilain(4), Vanessa A. Morais(4), Dominik Haddad(4), Wei-Ting Chen(3), Matthew G. Holt(3), Iryna Benilova(3), Renzo Mancuso(3), Christian Frezza(3), Luca Scorrano(3)