Renzo Mancuso

University of Antwerp — Belgium

Neuroscience · Life Sciences

33h-index8.2kcitations84works30.22yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(45), Alzheimer's disease research and treatments(22), Amyotrophic Lateral Sclerosis Research(22), Immune cells in cancer(13), Neurogenetic and Muscular Disorders Research(11)

Publications82 total

The Alzheimer’s disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states
Neuron·2025
C9orf72 hexanucleotide repeat expansions impair microglial response in ALS
Nature Neuroscience·2025· 5 citedOpen Access
Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of <scp>ALS</scp> Associated <scp>FUS</scp>
Aging Cell·2025Open Access
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease
Nature Communications·2025· 5 citedOpen Access
Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration
Nature Neuroscience·2025· 35 cited
The Alzheimer's Disease Risk Genes MS4A4A and MS4A6A Cooperate to Negatively Regulate TREM2 and Microglia States
SSRN Electronic Journal·2025Open Access
Neuroinflammation in Alzheimer disease
Nature reviews. Immunology·2024· 289 citedOpen Access
Proteome‐wide analyses identifies plasma immune regulators of amyloid‐beta progression
Alzheimer s & Dementia·2024Open Access
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease‐related Aβ pathology
Alzheimer s & Dementia·2024· 2 citedOpen Access
Deciphering a Single‐cell atlas and loss‐of‐function analysis revealing <i>ABCA7</i>’s transcriptome insights in Alzheimer’s disease
Alzheimer s & Dementia·2024Open Access
The Alzheimer’s Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states
2024· 5 citedOpen Access
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
EMBO Molecular Medicine·2024· 13 citedOpen Access
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems
Cell Reports·2024· 26 citedOpen Access
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression
Brain Behavior and Immunity·2024· 11 citedOpen Access
The <i>APOE</i> isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease
2024· 1 citedOpen Access
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
Molecular Neurodegeneration·2024· 6 citedOpen Access
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Nature Neuroscience·2024· 106 citedOpen Access
Immune Activation in Alzheimer Disease
Annual Review of Immunology·2024· 51 citedOpen Access
<scp>S100A8</scp> ‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice
Aging Cell·2024· 17 citedOpen Access
Xenografted human microglia in response to Alzheimer’s disease Aβ pathology
Alzheimer s & Dementia·2023Open Access
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Frequent Co-authors

Xavier Navarro(18), Bart De Strooper(17), Mark Fiers(13), Rosario Osta(12), Leen Wolfs(11), Nicola Fattorelli(10), Anna Martínez‐Muriana(10), Diego Gómez‐Nicola(8), Suresh Poovathingal(7), V. Hugh Perry(6), Sriram Balusu(6), Carlo Sala Frigerio(5), Tom Theys(5), Lutgarde Serneels(5), Sara Oliván(5), Nicola Thrupp(4), Ashley Lu(4), Evgenia Salta(4), An Snellinx(4), Johanna Van Den Daele(4)