Nicola Thrupp

La Jolla Institute for Immunology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index2.0kcitations16works2.32yr avg
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Research Topics

MicroRNA in disease regulation(5), Neurogenesis and neuroplasticity mechanisms(4), Neuroinflammation and Neurodegeneration Mechanisms(4), Circular RNAs in diseases(3), Alzheimer's disease research and treatments(2)

Publications16 total

Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo
2025Open Access
Putting computational models of immunity to the test—An invited challenge to predict B.pertussis vaccination responses
PLoS Computational Biology·2025· 1 citedOpen Access
NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease
Scientific Reports·2024· 6 citedOpen Access
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
Science·2023· 196 citedOpen Access
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease
Nature Neuroscience·2023· 58 citedOpen Access
microRNA-132 regulates gene expression programs involved in microglial homeostasis
iScience·2023· 34 citedOpen Access
Long noncoding RNA <i>MEG3</i> activates neuronal necroptosis in Alzheimer’s disease
2022· 5 cited
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Cell stem cell·2021· 174 citedOpen Access
Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease
2021Open Access
microRNA-132 regulates adult neural stem cells and their progeny to restore hippocampal neurogenesis and memory in Alzheimer’s disease
Research Portal (King's College London)·2021Open Access
Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans
Cell Reports·2020· 337 citedOpen Access
Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement
2020· 2 citedOpen Access
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
EMBO Molecular Medicine·2020· 270 citedOpen Access
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
Cell Reports·2019· 901 citedOpen Access
The ETSF : an e-infrastructure to bridge simulation and experiment
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B))·2012· 1 cited
The ETSF: An e-Infrastructure That Bridges Simulations and Experiments
Computing in Science & Engineering·2011· 25 cited

Frequent Co-authors

Mark Fiers(13), Bart De Strooper(12), Evgenia Salta(8), Dietmar Rudolf Thal(8), Katleen Craessaerts(7), Leen Wolfs(6), Carlo Sala Frigerio(5), Annerieke Sierksma(5), Sriram Balusu(5), Katrien Horré(5), Henrik Zetterberg(5), Renzo Mancuso(4), Wei-Ting Chen(4), Yannick Fourne(4), Hannah Walgrave(4), Sarah Snoeck(4), Amber Penning(4), Giorgia Tosoni(4), Nicola Fattorelli(3), Suresh Poovathingal(3)