Christoph Patsch

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index2.7kcitations45works3.22yr avg
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Research Topics

Pluripotent Stem Cells Research(12), CRISPR and Genetic Engineering(11), RNA Interference and Gene Delivery(8), 3D Printing in Biomedical Research(5), Virus-based gene therapy research(4)

Publications45 total

Angelman syndrome patient-derived neuron screen leads to clinical ASO rugonersen targeting <i>UBE3A</i>-ATS with long-lasting effect in monkeys
Nucleic Acids Research·2025· 2 citedOpen Access
A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity
Nature Communications·2025· 3 citedOpen Access
A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity
2024· 1 cited
A bottom‐up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors
Glia·2024· 1 citedOpen Access
Ready-to-use iPSC-derived microglia progenitors for the treatment of CNS disease in mouse models of neuropathic mucopolysaccharidoses
Nature Communications·2024· 12 citedOpen Access
A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors
2024Open Access
Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology
Cell Reports Medicine·2021· 63 citedOpen Access
Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages
Cell Death and Disease·2021· 45 citedOpen Access
Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
Frontiers in Immunology·2021· 57 citedOpen Access
Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells
Proceedings of the National Academy of Sciences·2020· 71 citedOpen Access
Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening
International Journal of Molecular Sciences·2020· 135 citedOpen Access
Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance
Scientific Reports·2020· 72 citedOpen Access
Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype
International Journal of Molecular Sciences·2019· 3 citedOpen Access
Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer's disease iPSC-derived neurons and mice
Molecular and Cellular Neuroscience·2019· 13 cited
Monolayer Generation of Vascular Endothelial Cells from Human Pluripotent Stem Cells
Methods in molecular biology·2019· 12 cited
ガンマセクレターゼ調節因子およびBACE阻害剤はAlzheimer病IPSC由来ニューロンおよびマウスにおける遺伝子発現を変化させることなくAβ産生を低下させる【JST・京大機械翻訳】
Molecular and Cellular Neuroscience·2019
Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study
Stem Cell Reports·2018· 168 citedOpen Access
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport
EBioMedicine·2017· 27 citedOpen Access
Generation of a homozygous GBA deletion human embryonic stem cell line
Stem Cell Research·2017· 6 citedOpen Access
Requirements for Using iPSC-Based Cell Models for Assay Development in Drug Discovery
Advances in biochemical engineering, biotechnology·2017· 13 cited
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Frequent Co-authors

Klaus Christensen(10), Ravi Jagasia(10), Martin Graf(10), Frank Edenhofer(10), Martin Ebeling(9), Stefan Aigner(8), Tom Dunkley(7), Filip Roudnicky(7), Jitao David Zhang(6), Arno Friedlein(6), Paolo Piraino(6), Mark Burcin(6), Meghan T. Miller(6), Simon Gutbier(5), Claas A. Meyer(5), Paul Cutler(5), Eva Thoma(4), Chad A. Cowan(4), Carlo Cusulin(4), Markus Britschgi(4)