Arno Friedlein

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index3.3kcitations39works0.02yr avg
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Research Topics

RNA Research and Splicing(5), Advanced Proteomics Techniques and Applications(4), Mass Spectrometry Techniques and Applications(4), Ubiquitin and proteasome pathways(4), Alzheimer's disease research and treatments(3)

Publications39 total

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration
Matrix Biology·2018· 38 citedOpen Access
mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis
Cell Reports·2016· 121 citedOpen Access
Characterization of a human pluripotent stem cell‐derived model of neuronal development using multiplexed targeted proteomics
PROTEOMICS - CLINICAL APPLICATIONS·2015· 21 cited
supplementary table 5 MSstats, clustering results and correlation with brain mRNA
2015
Supplementary table 6. Correlation of brain mRNA and in vitro protein data
2015
Supplementary table 3 peptide summary
2015
Supplementary table 2 SRM transition list (TSQ Vantage iSRM)
2015
Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine
Pharmaceutical Research·2014· 55 cited
Determination of free desmosine in human plasma and its application in two experimental medicine studies
Analytical Biochemistry·2013· 25 cited
Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog
Pharmaceutical Research·2012· 35 cited
Hydrophilic interaction chromatography of intact, soluble proteins
Journal of Chromatography A·2010· 52 cited
Use of the Immunodominant 18-Kilodalton Small Heat Shock Protein as a Serological Marker for Exposure to <i>Mycobacterium ulcerans</i>
Clinical and Vaccine Immunology·2006· 63 citedOpen Access
Direct Interactions between Subunits of CPSF and the U2 snRNP Contribute to the Coupling of Pre-mRNA 3′ End Processing and Splicing
Molecular Cell·2006· 196 citedOpen Access
Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells
European Journal of Pharmacology·2006· 42 cited
Biomarker Discovery by Imaging Mass Spectrometry
Molecular & Cellular Proteomics·2006· 144 citedOpen Access
Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions
PROTEOMICS·2006· 31 cited
A 13 kDa carboxy‐terminal fragment of ApoE stabilizes Abeta hexamers
Journal of Neurochemistry·2005· 26 cited
A New Yeast Poly(A) Polymerase Complex Involved in RNA Quality Control
PLoS Biology·2005· 564 citedOpen Access
Parkin Phosphorylation and Modulation of Its E3 Ubiquitin Ligase Activity
Journal of Biological Chemistry·2004· 116 citedOpen Access
The serum proteome of <b><i>Equus caballus</i></b>
PROTEOMICS·2004· 52 cited
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Frequent Co-authors

Hanno Langen(8), Tom Dunkley(8), Paul Cutler(8), Stefan Aigner(6), Martin Ebeling(6), Christoph Patsch(6), Paolo Piraino(6), Ravi Jagasia(6), Markus Wyss(5), Michael Fountoulakis(5), Meghan T. Miller(5), Walter Keller(4), Gabriele Wirtz(4), Roland Brugger(4), Willi Hunziker(4), Veronica Costa(4), Sebastian Lugert(4), Christian Haass(3), Jens Lamerz(3), Georges Martín(2)