Wolfgang Guba

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index3.5kcitations132works3.62yr avg
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Research Topics

Receptor Mechanisms and Signaling(33), Cannabis and Cannabinoid Research(30), Computational Drug Discovery Methods(27), Neuroscience and Neuropharmacology Research(23), Neuropeptides and Animal Physiology(12)

Publications132 total

Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists
Pharmacological Research·2025Open Access
Biased Signaling and Its Role in the Genesis of Short- and Long-Acting β<sub>2</sub>-Adrenoceptor Agonists
Biochemistry·2025Open Access
Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R
Nature Communications·2025· 5 citedOpen Access
A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay
Frontiers in Pharmacology·2025· 1 citedOpen Access
Profiling Allosteric Modulators of CB <sub>1</sub> R with an Allosteric Fluoroprobe
Angewandte Chemie International Edition·2025· 2 cited
Profiling Allosteric Modulators of CB <sub>1</sub> R with an Allosteric Fluoroprobe
Angewandte Chemie·2025
Novel Macrocyclic NLRP3 Inhibitors
Journal of Medicinal Chemistry·2024· 3 cited
Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects
CHIMIA International Journal for Chemistry·2024· 3 citedOpen Access
A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay
2024Open Access
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Frontiers in Pharmacology·2024· 10 citedOpen Access
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB <sub>1</sub> R)
Journal of Medicinal Chemistry·2024· 6 citedOpen Access
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
ACS Central Science·2024· 19 citedOpen Access
Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network
2024· 2 citedOpen Access
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R)
2024· 3 citedOpen Access
Visualization of membrane localization and functional state of CB2R pools by matched agonist and inverse agonist probe pairs
2024· 1 citedOpen Access
Visualization of membrane localization and the functional state of CB<sub>2</sub>R pools using matched agonist and inverse agonist probe pairs
Chemical Science·2024· 2 citedOpen Access
Flipping the GPCR Switch: Structure–Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
2023· 1 citedOpen Access
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors
Frontiers in Pharmacology·2023· 6 citedOpen Access
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells
Journal of the American Chemical Society·2023· 30 citedOpen Access
Using macromolecular phasing and refinement techniques for a small molecule gyrase inhibitor
Biophysical Journal·2023Open Access
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Frequent Co-authors

Uwe Grether(10), Christoph Ullmer(8), Matthias Nettekoven(7), Mark Rogers‐Evans(6), Martin Ståhl(6), Erick M. Carreira(6), Tanja Schulz‐Gasch(5), Matthias Rarey(5), Caterina Bissantz(5), Jürgen Fingerle(5), Roman C. Sarott(5), Olivier Roche(4), Manfred Kansy(4), Werner Neidhart(4), A. Kuglstatter(4), Emmanuel Pinard(4), Harald Mauser(4), Robert Narquizian(4), Jens‐Uwe Peters(4), Stefanie Bendels(4)