Caterina Bissantz

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index4.4kcitations59works46.82yr avg
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Research Topics

Receptor Mechanisms and Signaling(20), Neuropeptides and Animal Physiology(12), Antibiotic Resistance in Bacteria(11), Antibiotics Pharmacokinetics and Efficacy(10), Chemical Synthesis and Analysis(9)

Publications59 total

<i>In vitro</i> pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against <i>Acinetobacter baumannii</i>
Antimicrobial Agents and Chemotherapy·2025· 1 citedOpen Access
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Frontiers in Pharmacology·2024· 10 citedOpen Access
Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter
Nature·2024· 2 citedOpen Access
Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii
International Journal of Antimicrobial Agents·2024Open Access
Translational PK/PD for the Development of Novel Antibiotics—A Drug Developer’s Perspective
Antibiotics·2024· 8 citedOpen Access
A novel antibiotic class targeting the lipopolysaccharide transporter
Nature·2024· 260 citedOpen Access
2109. <i>In vitro</i> and <i>in vivo</i> Killing Kinetics of Zosurabalpin (RG6006) Against <i>Acinetobacter baumannii</i>
Open Forum Infectious Diseases·2023· 2 citedOpen Access
Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition
ACS Medicinal Chemistry Letters·2023· 5 citedOpen Access
Estimating Unbound Drug Concentrations in Simulated Human Lung Fluid: Relevance to Lung Antibiotic PKPD
Molecular Pharmaceutics·2023· 8 cited
Transcriptomic data to support in vitro semimechanistic PK/PD modelling of Polymyxin B against Acinetobacter baumannii
SPIRE - Sciences Po Institutional REpository·2023
CCDC 1981521: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Translating pharmacology models effectively to predict therapeutic benefit
Drug Discovery Today·2022· 14 citedOpen Access
Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
Journal of Medicinal Chemistry·2020· 21 citedOpen Access
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease
ACS Medicinal Chemistry Letters·2020· 23 citedOpen Access
Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder
Journal of Medicinal Chemistry·2020· 60 cited
Meropenem–nacubactam activity against AmpC-overproducing and KPC-expressing Pseudomonas aeruginosa in a neutropenic murine lung infection model
International Journal of Antimicrobial Agents·2019· 34 cited
A novel mechanism-based pharmacokinetic–pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria
Journal of Antimicrobial Chemotherapy·2019· 18 cited
Safety screening in early drug discovery: An optimized assay panel
Journal of Pharmacological and Toxicological Methods·2019· 78 cited
Efficacy of Human-Simulated Epithelial Lining Fluid Exposure of Meropenem-Nacubactam Combination against Class A Serine β-Lactamase-Producing <i>Enterobacteriaceae</i> in the Neutropenic Murine Lung Infection Model
Antimicrobial Agents and Chemotherapy·2019· 23 citedOpen Access
1368. Assessment of the In Vivo Efficacy of Human-Simulated Epithelial Lining Fluid (ELF) Exposure of Meropenem/Nacubactam (MEM/NAC) Combination Against β-Lactamase-Producing Enterobacteriaceae in Neutropenic Lung Infection Model
Open Forum Infectious Diseases·2018· 3 citedOpen Access
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Frequent Co-authors

Claudia Zampaloni(10), Hasane Ratni(7), Wolfgang Guba(6), Pari Malherbe(6), Anne Marcuz(6), Martin Ståhl(5), Didier Rognan(5), Lotte Winther(5), Patrizio Mattei(4), Carina Cantrill(4), Thomas J. Woltering(4), Hans Richter(4), Roland Jakob‐Roetne(4), David P. Nicolau(4), Claudia Kratzeisen(4), Joseph G. Wettstein(4), Rainer E. Martin(4), Will Spooren(4), Bernd Kuhn(3), Jean‐Michel Adam(3)