John F. Engelhardt

University of Iowa — United States

Medicine · Health Sciences

94h-index31.2kcitations431works4.32yr avg
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Research Topics

Neonatal Respiratory Health Research(114), Virus-based gene therapy research(101), Cystic Fibrosis Research Advances(96), Tracheal and airway disorders(52), Respiratory viral infections research(44)

Publications431 total

LUNAR LNP delivery of CFTR mRNA restores channel function and improves mucociliary clearance in ferret cystic fibrosis airways
Molecular Therapy·2025Open Access
Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis
npj Regenerative Medicine·2025Open Access
172 Improving mucociliary clearance by combining adrenergic and cholinergic agonists in CF airways
Journal of Cystic Fibrosis·2025
201 Basal progenitor cells in the ferret trachea and bronchi retain cell- intrinsic programming for goblet cell specification
Journal of Cystic Fibrosis·2025
Downstream Workflows for Intermediate Purification of Lentiviral Vectors Using Tangential Flow Filtration and AEX Membrane Chromatography
Engineering in Life Sciences·2025· 1 citedOpen Access
313 Mapping of the cellular immune epitopes of Cre, Gaussia luciferase, and human CFTRΔR protein in ferret and murine models
Journal of Cystic Fibrosis·2025
344 Analysis of CFTR expression and function in the kidney
Journal of Cystic Fibrosis·2025
Ionocyte CFTR Coordinates Chloride Absorption and Secretion to Balance Airway Fluid
American Journal of Respiratory and Critical Care Medicine·2025· 2 cited
PRenatal mOdulator treatment to PrEvent CF complicaTions (PROTECT) workshop report
Journal of Cystic Fibrosis·2025· 5 citedOpen Access
Development of a robust large scale downstream processing of lentiviral vectors using tangential flow filtration
Separation and Purification Technology·2025· 2 citedOpen Access
Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators
UNC Libraries·2025Open Access
A Versatile Reporter Platform for Evaluating HDR- and NHEJ-Based Genome Editing in Airway Epithelial Cell Cultures Using an rAAV Vector
Viruses·2025Open Access
The impact of breast cancer treatment on young women’s body image and sexual health.
Journal of Clinical Oncology·2025
Recombinant Adeno-Associated Virus Vector Mediated Gene Editing in Proliferating and Polarized Cultures of Human Airway Epithelial Cells
Human Gene Therapy·2025· 1 citedOpen Access
CFTR-Mediated Ion and Fluid Transport by Primary Ferret AT2 Epithelia
American Journal of Respiratory and Critical Care Medicine·2025
The Ferret Bleomycin-Induced Model of Lung Injury Shares Features of Idiopathic Pulmonary Fibrosis in Humans
American Journal of Respiratory and Critical Care Medicine·2025
CFTR Modulator VX770 Inhibits Cell Senescence and Mitigates Bleomycin Induced Pulmonary Fibrosis in Mouse Lung
American Journal of Respiratory and Critical Care Medicine·2025
Characterization of Ovalbumin-Induced Allergic Airway Inflammation in Ferrets
American Journal of Respiratory and Critical Care Medicine·2025
Tangential Flow Filtration Cassettes for Robust Ultrafiltration and Diafiltration in Downstream Lentiviral Vector Processing
Cytotherapy·2025
Novel Cystic Fibrosis Ferret Model Enables Visualization of CFTR Expression Cells and Genetic CFTR Reactivation
Human Gene Therapy·2025· 3 citedOpen Access
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Frequent Co-authors

James M. Wilson(11), Ziying Yan(9), Dongsheng Duan(8), Ralf M. Zwacka(6), Yongping Yue(5), Yulong Zhang(5), Weihong Zhou(5), James R. Yankaskas(4), Yiping Yang(4), Mariann Grossman(4), Jusan Yang(4), Lorita Dudus(4), Xiaoming Liu(4), Purushothama Rao Tata(3), Steven M. Rowe(3), Richard C. Boucher(3), Richard H. Simon(3), Scott H. Randell(3), Xingshen Sun(3), Monica L. Zepeda(3)