Ralf M. Zwacka

University of Essex — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index5.0kcitations72works0.02yr avg
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Research Topics

Cell death mechanisms and regulation(27), RNA Interference and Gene Delivery(13), Virus-based gene therapy research(11), Mitochondrial Function and Pathology(7), Nitric Oxide and Endothelin Effects(6)

Publications72 total

MSC-delivered High-Affinity Variants of soluble PD1 lead to tumour regression
2025Open Access
Thieno[2,3-b]pyridine compounds potently inhibit prostate cancer growth and motility
Endocrine Oncology·2025Open Access
Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer
Cancer Nanotechnology·2023· 9 citedOpen Access
Supplementary Data from TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
2023Open Access
Supplementary Data from TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
2023Open Access
Data from TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
2023Open Access
Data from TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
2023Open Access
Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer
Research Square (Research Square)·2023Open Access
The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
Nature Communications·2021· 88 citedOpen Access
Fas-threshold signalling in MSCs promotes pancreatic cancer progression and metastasis
Cancer Letters·2021· 39 cited
Soluble trail has better efficacy than full-length membrane-bound trail, and in combination with akti blocks pro-metastatic cytokine production in prostate cancer cells
Cytotherapy·2021
Antiandrogens Target TMPRSS2 and Reduce SARS-CoV-2 Virus Entry in Lung Cells
Journal of the Endocrine Society·2021· 1 citedOpen Access
Fas-threshold signalling in MSCs causes tumour progression and metastasis
Cytotherapy·2021
Enzalutamide, a prostate cancer therapeutic, downregulates TMPRSS2 in lung and reduces cellular entry of SARS-CoV-2
Research Square (Research Square)·2021· 2 citedOpen Access
Fas-threshold signalling in MSCs causes tumour progression and metastasis
2020
MSC.sTRAIL Has Better Efficacy than MSC.FL-TRAIL and in Combination with AKTi Blocks Pro-Metastatic Cytokine Production in Prostate Cancer Cells
Cancers·2019· 26 citedOpen Access
The future of mesenchymal stem cell-based therapeutic approaches for cancer – From cells to ghosts
Cancer Letters·2017· 117 cited
Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Cell Death and Differentiation·2017· 29 citedOpen Access
Stem Cell Regulation by Death Ligands and Their Use in Cell Therapy
Resistance to targeted anti-cancer therapeutics·2017· 1 cited
A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells
BMC Research Notes·2016· 5 citedOpen Access
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Frequent Co-authors

Andrea Mohr(20), John F. Engelhardt(16), Larry W. Oberley(7), Klaus‐Michael Debatin(6), Lorita Dudus(5), Hans Weiher(5), Simone Fulda(4), Laura Deedigan(4), Stella Maris Albarenque(4), Rui Yu(4), Lars Behrend(3), Weihong Zhou(3), Jeff Halldorson(3), Malcolm G. Dunlop(3), Michael W. Epperly(3), Joel S. Greenberger(3), Alexander Reuter(3), Chirlei Klein Büneker(3), Greg N. Brooke(3), Ernest W.N. Lam(3)