Harald Rouha

Medicine · Health Sciences

14h-index807citations24works2.52yr avg
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Research Topics

Antimicrobial Resistance in Staphylococcus(10), Mosquito-borne diseases and control(5), Immune Response and Inflammation(4), Pneumonia and Respiratory Infections(4), Respiratory viral infections research(4)

Publications24 total

RSM01, a novel respiratory syncytial virus monoclonal antibody: preclinical characterization and results of a first-in-human, randomised clinical trial
BMC Infectious Diseases·2024· 5 citedOpen Access
RSM01, a Novel Respiratory Syncytial Virus Monoclonal Antibody: Preclinical Characterization and Results of a First-in-Human, Randomised Clinical Trial
2024Open Access
Molecular mechanism of leukocidin GH–integrin CD11b/CD18 recognition and species specificity
Proceedings of the National Academy of Sciences·2019· 27 citedOpen Access
Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study of the Penetration of a Monoclonal Antibody Combination (ASN100) Targeting <i>Staphylococcus aureus</i> Cytotoxins in the Lung Epithelial Lining Fluid of Healthy Volunteers
Antimicrobial Agents and Chemotherapy·2019· 58 citedOpen Access
Preventing lung pathology and mortality in rabbit Staphylococcus aureus pneumonia models with cytotoxin-neutralizing monoclonal IgGs penetrating the epithelial lining fluid
Scientific Reports·2019· 25 citedOpen Access
Adaptation of the <i>Staphylococcus aureus</i> leukocidin LukGH for the rabbit host by protein engineering
Biochemical Journal·2018· 5 cited
Age-related changes in the levels and kinetics of pulmonary cytokine and chemokine responses to Streptococcuspneumoniae in mouse pneumonia models
Cytokine·2018· 14 cited
1388. Dose Discrimination for ASN100: Bridging from Rabbit Survival Data to Predicted Activity in Humans Using a Minimal Physiologically Based Pharmacokinetic (mPBPK) Model
Open Forum Infectious Diseases·2018Open Access
Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in<i>in vitro</i>and<i>in vivo</i>lung infection models using monoclonal antibodies
Virulence·2018· 17 citedOpen Access
Disarming <i>Staphylococcus aureus</i> from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies
Figshare·2018Open Access
Disarming <i>Staphylococcus aureus</i> from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies
Virulence·2017· 40 citedOpen Access
Selective sensitization of human neutrophils to LukGH mediated cytotoxicity by Staphylococcus aureus and IL-8
Journal of Infection·2017· 14 citedOpen Access
Prevention of Lung Pathology and Mortality in Rabbit Staphylococcus aureus Pneumonia with Cytotoxin-Neutralizing Monoclonal IgGs that Penetrate Epithelial Lining Fluid
Open Forum Infectious Diseases·2017· 2 citedOpen Access
Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin
Antimicrobial Agents and Chemotherapy·2016· 71 citedOpen Access
Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of<i>Staphylococcus aureus</i>for the generation of neutralizing antibodies
mAbs·2016· 48 citedOpen Access
Membrane Anchors of the Structural Flavivirus Proteins and Their Role in Virus Assembly
Journal of Virology·2016· 56 citedOpen Access
Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins of <i>Staphylococcus aureus</i> with a single human monoclonal antibody
mAbs·2014· 141 citedOpen Access
Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the Staphylococcus aureus Bi-component Toxin LukGH
Journal of Biological Chemistry·2014· 60 citedOpen Access
α-Hemolysin Activity of Methicillin-Susceptible <i>Staphylococcus aureus</i> Predicts Ventilator-associated Pneumonia
American Journal of Respiratory and Critical Care Medicine·2014· 61 cited
Crystal structure of the octameric pore complex of the Staphylococcus aureus Bi-component Toxin LukGH
2014
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Frequent Co-authors

Eszter Nagy(16), Adriana Badarau(14), Lukas Stulik(14), Zehra Visram(8), Barbara Maierhofer(8), Karin Groß(8), Susanne Weber(8), Stefan Malafa(7), Ivana Doležílková(6), Irina Mirkina(5), Philipp Janesch(5), Gábor Nagy(4), Manuel Zerbs(4), Zoltán Magyarics(3), Michaela Jägerhofer(3), Astrid Teubenbacher(3), Gerhild Zauner(3), Christian W. Mandl(3), Derek T. Logan(3), Michael B. Battles(2)