Tatyana Dobreva

University of Uyo — Nigeria

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index604citations13works0.02yr avg
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Research Topics

Virus-based gene therapy research(5), CRISPR and Genetic Engineering(4), Single-cell and spatial transcriptomics(4), T-cell and B-cell Immunology(2), Advanced biosensing and bioanalysis techniques(2)

Publications13 total

Single-cell RNA sequencing of 76,535 capillary PBMCs from 3 donors across 28 samples, freshly isolated or on ice for 24h with manual 4-layer annotation hierarchy
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Single-cell RNA sequencing of 76,535 capillary PBMCs from 3 donors across 28 samples, freshly isolated or on ice for 24h with manual 4-layer annotation hierarchy
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Deep Parallel Characterization of AAV Tropism and AAV-Mediated Transcriptional Changes via Single-Cell RNA Sequencing
Frontiers in Immunology·2021· 64 citedOpen Access
Deep parallel characterization of AAV tropism and AAV-mediated transcriptional changes via single-cell RNA sequencing
2021· 11 citedOpen Access
Single cell profiling of capillary blood enables out of clinic human immunity studies
Scientific Reports·2020· 8 citedOpen Access
Enabling out-of-clinic human immunity studies via single-cell profiling of capillary blood
2020Open Access
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
Nature Communications·2020· 43 citedOpen Access
Evolution and Investigation of Engineered AAV Capsids Exhibiting Enhanced Transduction of the Central Nervous System with or without Murine Strain Specificity
2020
A Computational and Experimental Platform for Detecting Full Transcriptome Cell Type Tropism of Lowly Expressed Barcoded and Pooled AAV Variants via Single-Cell RNA Sequencing
CaltechAUTHORS (California Institute of Technology)·2020
In-Depth Parallel Profiling of Tissue and Cell-Type Tropism of AAV Variants by Single-Cell RNA Sequencing
CaltechAUTHORS (California Institute of Technology)·2020
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
Nature Methods·2020· 195 citedOpen Access
Engineering Artificial Somatosensation Through Cortical Stimulation in Humans
Frontiers in Systems Neuroscience·2018· 95 citedOpen Access
Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow
Science Translational Medicine·2017· 189 cited

Frequent Co-authors

David Alan Brown(10), Viviana Gradinaru(8), Matt Thomson(6), Michael Altermatt(4), Jong Hwee Park(4), Xiaozhe Ding(3), Alon Greenbaum(3), Min Jee Jang(3), Sripriya Ravindra Kumar(2), Timothy F. Miles(2), Xinhong Chen(2), Qin Huang(2), Yicheng Luo(2), Pétur Helgi Einarsson(2), Benjamin E. Deverman(2), Sisi Chen(2), Alexander Wang(2), Eduardo da Veiga Beltrame(2), Vincent Steffens(2), Christopher S. McGinnis(2)