Susan J. Tudhope

Newcastle University — United Kingdom

Medicine · Health Sciences

17h-index1.3kcitations29works0.02yr avg
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Research Topics

Chronic Lymphocytic Leukemia Research(7), NF-κB Signaling Pathways(6), Metabolism, Diabetes, and Cancer(4), Asthma and respiratory diseases(3), Cancer-related Molecular Pathways(3)

Publications29 total

Abstract 5331: Orthosteric CDK2 kinase inhibitors have a distinctive profile when compared to genetic perturbation of CDK2 in CCNE1-amplified and non-amplified tumor cell lines
Cancer Research·2025
Expression and Activity of the NF-κB Subunits in Chronic Lymphocytic Leukaemia: A Role for RelB and Non-Canonical Signalling
Cancers·2023· 4 citedOpen Access
Fragment expansion with NUDELs - poised DNA-encoded libraries
Research Square (Research Square)·2023· 1 citedOpen Access
Fragment expansion with NUDELs – poised DNA-encoded libraries
Chemical Science·2023· 10 citedOpen Access
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase
Journal of Medicinal Chemistry·2021· 16 citedOpen Access
Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia
British Journal of Cancer·2020· 19 citedOpen Access
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
Journal of Clinical Investigation·2019· 65 citedOpen Access
Opposite effects of a glucokinase activator and metformin on glucose‐regulated gene expression in hepatocytes
Diabetes Obesity and Metabolism·2017· 27 cited
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines
Journal of Medicinal Chemistry·2016· 113 citedOpen Access
Targeting Ikkα in CLL: Inhibition of Non-Canonical NF-κb Signaling Decreases Survival and Proliferation of CD40L-Stimulated Primary CLL Cells
Blood·2016· 1 cited
The Role of HOXA4 in Chronic Lymphocytic Leukaemia Progression and Response to Therapy
Blood·2016
Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD
European Respiratory Journal·2016· 74 citedOpen Access
NF-κB subunits bind the EZH2 promoter in fibroblasts and B-cells.
Figshare·2015Open Access
NF-κB2 controls Rb phosphorylation, EZH2 expression and senescence through CDK4 and CDK6 regulation.
Figshare·2015Open Access
PARP1 expression, activity and<i>ex vivo</i>sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia
Oncotarget·2015· 30 citedOpen Access
Novel small molecule IKK alpha inhibitors inhibit non- canonical NF-kappa B signaling and survival of primary CLL cells
Leukemia & lymphoma/Leukemia and lymphoma·2015
Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
PLoS Genetics·2014· 101 citedOpen Access
Glucose Induces Protein Targeting to Glycogen in Hepatocytes by Fructose 2,6-Bisphosphate-Mediated Recruitment of MondoA to the Promoter
Molecular and Cellular Biology·2012· 34 citedOpen Access
P B S-1086, a “Pan-Rel” Inhibitor, Decreases Viability of Chronic Lymphocytic Leukemia Cells
Blood·2012· 2 cited
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes
Biochemical Journal·2012· 109 cited
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Frequent Co-authors

Elaine Willmore(12), Peter J. Barnes(6), Louise Donnelly(6), Stephen R. Wedge(6), Jonathan P. Wallis(6), Catherine Arden(5), John L. Petrie(5), Loranne Agius(5), Neil D. Perkins(5), Jill V. Hunter(5), Helen Marr(5), Mathew P. Martin(4), M.E.M. Noble(4), Ziad H. Al‐Oanzi(4), G.C.A. Junge(4), Evan A. Mulligan(4), Scott Marshall(4), Céline Cano(3), Howard C. Towle(3), Alessio Iannetti(3)