Loranne Agius

Medicine · Health Sciences

46h-index6.6kcitations211works1.82yr avg
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Research Topics

Pancreatic function and diabetes(96), Metabolism, Diabetes, and Cancer(73), Diet, Metabolism, and Disease(38), Diet and metabolism studies(33), Liver Disease Diagnosis and Treatment(32)

Publications211 total

Glucokinase Activators. A Humbling Lesson in Drug Development
Diabetes·2025· 1 citedOpen Access
Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants
Biochemical Pharmacology·2024· 3 citedOpen Access
Compromised chronic efficacy of a Glucokinase Activator AZD1656 in mouse models for common human <i>GCKR</i> variants
2024Open Access
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency
Molecular Metabolism·2024· 3 citedOpen Access
The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326
Molecular Metabolism·2023· 20 citedOpen Access
Review for "Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?"
2021Open Access
Review for "Pharmacokinetics, safety, tolerability, and efficacy of cotadutide, a GLP ‐1 and glucagon receptor dual agonist, in phase 1/2 trials in overweight or obese participants of Asian descent with or without T2D"
2021Open Access
Peer Review #2 of "Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway (v0.1)"
2020Open Access
The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective
Frontiers in Endocrinology·2020· 26 citedOpen Access
Review for "Inhibition of fatty acid synthase with &lt;scp&gt;FT&lt;/scp&gt; ‐4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with &lt;scp&gt;NAFLD&lt;/scp&gt; non‐alcoholic fatty liver disease: results from two early phase randomized trials"
2020Open Access
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse
Ecotoxicology and Environmental Safety·2020· 21 citedOpen Access
Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte <scp>ATP</scp> homeostasis during substrate challenge
Diabetes Obesity and Metabolism·2020· 14 citedOpen Access
Author response for "Chronic Glucokinase Activator treatment activates liver Carbohydrate Response Element binding protein and improves hepatocyte &lt;scp&gt;ATP&lt;/scp&gt; homeostasis during substrate challenge"
2020
The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
International Journal of Molecular Sciences·2020· 160 citedOpen Access
Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
Journal of Biological Chemistry·2020· 33 citedOpen Access
Identification of <i>C</i>-β-<scp>d</scp>-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: <i>In Silico</i> Design, Synthesis, <i>in Vitro</i> Kinetics, and <i>ex Vivo</i> Studies
ACS Chemical Biology·2019· 15 citedOpen Access
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism
Journal of Biological Chemistry·2018· 80 citedOpen Access
The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha
Biochemical and Biophysical Research Communications·2018· 16 cited
Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
BMC Biology·2018· 87 citedOpen Access
Additional file 20: of Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
Figshare·2018Open Access
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Frequent Co-authors

Matthew Peak(8), Susan Aiston(6), Catherine Arden(5), Joan J. Guinovart(3), John L. Petrie(3), Alex J. Lange(3), K. G. M. M. Alberti(3), Gillian Patman(3), Helen L. Reeves(3), Christopher B. Newgard(2), Anna M. Gómèz‐Foix(2), Victoria A. Payne(2), Matthew P. Coghlan(2), Susan J. Tudhope(2), Ziad H. Al‐Oanzi(2), Howard C. Towle(2), Mohammed Hasan Mukhtar(2), D H Williamson(2), K. G. M. M. Alberti(2), Mark Walker(2)