Edward Hurrell

Heptares Therapeutics (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.9kcitations18works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(8), Adenosine and Purinergic Signaling(8), Enterobacteriaceae and Cronobacter Research(5), Antibiotic Resistance in Bacteria(4), Neuropeptides and Animal Physiology(4)

Publications18 total

From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease
Cell·2021· 87 citedOpen Access
Small molecule AZD4635 inhibitor of A<sub>2A</sub>R signaling rescues immune cell function including CD103<sup>+</sup> dendritic cells enhancing anti-tumor immunity
Journal for ImmunoTherapy of Cancer·2020· 96 citedOpen Access
From Structure to Clinic: Discovery of A M1 Muscarinic Acetylcholine Receptor Agonist for the Treatment of Memory Loss in Alzheimer's Disease
SSRN Electronic Journal·2020· 1 citedOpen Access
Structure-based drug design of chromone antagonists of the adenosine A<sub>2A</sub> receptor
MedChemComm·2014· 27 cited
Identification of Novel Adenosine A<sub>2A</sub> Receptor Antagonists by Virtual Screening
Journal of Medicinal Chemistry·2012· 133 citedOpen Access
Discovery of 1,2,4-Triazine Derivatives as Adenosine A<sub>2A</sub> Antagonists using Structure Based Drug Design
Journal of Medicinal Chemistry·2012· 301 citedOpen Access
Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine
2011
Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine
Structure·2011· 546 citedOpen Access
Thermostabilised adenosine A2A receptor in complex with caffeine
2011
Thermostabilised adenosine A2A receptor in complex with XAC
2011· 1 cited
Gentamicin protection assay with rat rBCEC4 cells
Figshare·2011Open Access
Thermostabilised Adenosine A2A Receptor
2010
The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery
Neuropharmacology·2010· 158 cited
Neonatal enteral feeding tubes as loci for colonisation by members of the Enterobacteriaceae
BMC Infectious Diseases·2009· 139 citedOpen Access
Biofilm formation on enteral feeding tubes by Cronobacter sakazakii, Salmonella serovars and other Enterobacteriaceae
International Journal of Food Microbiology·2009· 103 citedOpen Access
Characterization of an extended-spectrum beta-lactamase Enterobacter hormaechei nosocomial outbreak, and other Enterobacter hormaechei misidentified as Cronobacter (Enterobacter) sakazakii
Microbiology·2008· 73 cited
Virulence studies of Enterobacter sakazakiiisolates associated with a neonatal intensive care unit outbreak
BMC Microbiology·2008· 127 citedOpen Access
Enterobacter sakazakii invades brain capillary endothelial cells, persists in human macrophages influencing cytokine secretion and induces severe brain pathology in the neonatal rat
Microbiology·2007· 124 cited

Frequent Co-authors

Miles Congreve(10), Fiona H. Marshall(10), N.J. Robertson(8), James C. Errey(8), A.S. Dore(6), Irene W. Ng(6), Malcolm Weir(6), Christopher J. Langmead(6), Stephen Forsythe(6), Kaspar Hollenstein(5), B.G. Tehan(5), Francesca Magnani(4), Christopher G. Tate(4), Stephen P. Andrews(4), Andrei Zhukov(4), Stacy M. Townsend(4), M. Weir(4), K.A. Bennett(3), Jonathan S. Mason(3), Benjamin G. Tehan(3)