Malvika Kaul

Rutgers, The State University of New Jersey — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index1.9kcitations41works0.02yr avg
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Research Topics

Bacterial Genetics and Biotechnology(12), Antibiotic Resistance in Bacteria(12), RNA and protein synthesis mechanisms(12), Antimicrobial Resistance in Staphylococcus(8), Cancer therapeutics and mechanisms(7)

Publications41 total

Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant <i>Staphylococcus aureus</i>
ACS Chemical Biology·2023· 12 citedOpen Access
Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus
Medicinal Chemistry Research·2022· 8 citedOpen Access
Impact of neurological disorders on insomnia
Elsevier eBooks·2021
Sleep Telemedicine
Sleep Disorders·2021· 1 cited
Advances in the structural studies of antibiotic potentiators against Escherichia coli
Bioorganic & Medicinal Chemistry·2019· 12 citedOpen Access
Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli
European Journal of Medicinal Chemistry·2019· 18 citedOpen Access
β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy·2017· 30 citedOpen Access
Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in <i>Staphylococcus aureus</i> FtsZ
ACS Chemical Biology·2017· 67 citedOpen Access
Staphylococcus aureus FtsZ 12-316 complexed with TXA707
2017
Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy·2016· 44 citedOpen Access
TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced <i>In Vivo</i> Efficacy against Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy·2015· 108 citedOpen Access
TXA497 as a topical antibacterial agent: Comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin
International Journal of Pharmaceutics·2014· 15 cited
Matriptase Autoactivation Is Tightly Regulated by the Cellular Chemical Environments
PLoS ONE·2014· 29 citedOpen Access
Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria
Biochemical Pharmacology·2014· 35 cited
Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723
Biochemical Pharmacology·2013· 46 cited
An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy <i>In Vivo</i>
Antimicrobial Agents and Chemotherapy·2013· 58 citedOpen Access
Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit
Journal of Histochemistry & Cytochemistry·2013· 11 citedOpen Access
Matriptase Regulates Proliferation and Early, but Not Terminal, Differentiation of Human Keratinocytes
Journal of Investigative Dermatology·2013· 42 citedOpen Access
Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines
Bioorganic & Medicinal Chemistry Letters·2013· 157 citedOpen Access
Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis
Biochimie·2013· 26 citedOpen Access
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Frequent Co-authors

Daniel S. Pilch(31), Edmond J. LaVoie(21), Ajit K. Parhi(20), Christopher M. Barbieri(10), Lilly Mark(6), Yongzheng Zhang(5), John E. Kerrigan(4), Yacov Ron(4), Cody Kelley(4), Joseph P. Dougherty(3), Junso Fujita(3), Hiroyoshi Matsumura(3), Yongzheng Zhang(3), Jehng-Kang Wang(3), Michael D. Johnson(3), Chen‐Yong Lin(3), Edgar Ferrer-González(3), Hong Yu(2), Annmarie L. Pacchia(2), Martin E. Adelson(2)