Edmond J. LaVoie

Rutgers, The State University of New Jersey — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index7.9kcitations219works5.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(65), Carcinogens and Genotoxicity Assessment(36), Synthesis and Biological Evaluation(32), DNA and Nucleic Acid Chemistry(25), Bioactive Compounds and Antitumor Agents(20)

Publications219 total

A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens
Antibiotics·2024· 5 citedOpen Access
Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant <i>Staphylococcus aureus</i>
ACS Chemical Biology·2023· 12 citedOpen Access
Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria
Medicinal Chemistry Research·2022· 2 citedOpen Access
Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus
Medicinal Chemistry Research·2022· 8 citedOpen Access
Novel MreB Inhibitors with Antibacterial Activity Against Gram (-) Bacteria
2022Open Access
TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens
Antibiotics·2022· 16 citedOpen Access
Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens
Scientific Reports·2019· 34 citedOpen Access
S. aureus FtsZ in complex with 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)-2,6-difluorobenzamide (compound 2)
2019
Advances in the structural studies of antibiotic potentiators against Escherichia coli
Bioorganic & Medicinal Chemistry·2019· 12 citedOpen Access
Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli
European Journal of Medicinal Chemistry·2019· 18 citedOpen Access
Aryl and Arylalkyl Substituted 3‐Hydroxypyridin‐2(1<i>H</i>)‐ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease
ChemMedChem·2019· 7 citedOpen Access
β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy·2017· 30 citedOpen Access
Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in <i>Staphylococcus aureus</i> FtsZ
ACS Chemical Biology·2017· 67 citedOpen Access
Staphylococcus aureus FtsZ 12-316 complexed with TXA707
2017
Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy·2016· 44 citedOpen Access
TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced <i>In Vivo</i> Efficacy against Methicillin-Resistant Staphylococcus aureus
Antimicrobial Agents and Chemotherapy·2015· 108 citedOpen Access
Phenyl Substituted 4-Hydroxypyridazin-3(2<i>H</i>)-ones and 5-Hydroxypyrimidin-4(3<i>H</i>)-ones: Inhibitors of Influenza A Endonuclease
Journal of Medicinal Chemistry·2014· 53 citedOpen Access
TXA497 as a topical antibacterial agent: Comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin
International Journal of Pharmaceutics·2014· 15 cited
Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria
Biochemical Pharmacology·2014· 35 cited
Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723
Biochemical Pharmacology·2013· 46 cited
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Frequent Co-authors

Leroy F. Liu(18), Daniel S. Pilch(17), Ajit K. Parhi(11), Angela Liu(10), Malvika Kaul(9), Dietrich Hoffmann(7), Chiang Yu(6), Alexander L. Ruchelman(6), Tsai‐Kun Li(6), Joseph E. Rice(5), Stephen S. Hecht(5), Chi‐Tang Ho(4), Barbara Gatto(4), Sudhir Singh(4), Lilly Mark(4), Yongzheng Zhang(4), Suzanne G. Rzuczek(4), Eddy Arnold(4), Mingfu Wang(3), Jung Sun Kim(3)