Alexander L. Ruchelman

Bristol-Myers Squibb (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.5kcitations25works0.52yr avg
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Research Topics

Cancer therapeutics and mechanisms(15), Synthesis and Biological Evaluation(8), Synthesis and biological activity(6), Bioactive Compounds and Antitumor Agents(5), Protein Degradation and Inhibitors(4)

Publications25 total

Correction to “Evolution of the Synthesis Route for CC-99677: From Discovery Towards Commercialization”
Organic Process Research & Development·2025
Integrating Process Safety Consideration to Enhance Route Development and Optimization
Organic Process Research & Development·2025· 1 cited
Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie
Medicinal Chemistry Research·2022Open Access
Pd-Catalyzed Chemoselective O-Benzylation of Ambident 2-Quinolinone Nucleophiles
ACS Catalysis·2022· 11 citedOpen Access
Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
Cancer Research·2017
Protein Degradation via CRL4<sup>CRBN</sup> Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Journal of Medicinal Chemistry·2017· 76 cited
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
Nature·2016· 629 cited
Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation
Tetrahedron Asymmetry·2015· 22 cited
Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters·2012· 57 cited
1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4
Bioorganic & Medicinal Chemistry·2011· 28 citedOpen Access
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity
Bioorganic & Medicinal Chemistry·2006· 20 cited
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents
Bioorganic & Medicinal Chemistry·2005· 53 cited
Dimethoxybenzo[i]phenanthridine‐12‐carboxylic Acid Derivatives and 6H‐Dibenzo[c,h][2,6]naphthyridin‐5‐ones with Potent Topoisomerase I‐Targeting Activity and Cytotoxicity.
ChemInform·2005
5-(2-Aminoethyl)dibenzo[<i>c</i>,<i>h</i>][1,6]naphthyridin-6-ones:  Variation of <i>N</i>-Alkyl Substituents Modulates Sensitivity to Efflux Transporters Associated with Multidrug Resistance
Journal of Medicinal Chemistry·2005· 110 cited
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity
Bioorganic & Medicinal Chemistry Letters·2004· 18 cited
Cytotoxicity of 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-Indeno[1,2-c]isoquinolin-5,11-diones in Tumor Cells Sensitive and Resistant to Camptothecin Analogs
Letters in Drug Design & Discovery·2004· 7 cited
Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity
Bioorganic & Medicinal Chemistry·2004· 34 cited
11H-Isoquino[4,3-c]cinnolin-12-ones
Bioorganic & Medicinal Chemistry·2004· 80 cited
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
PubMed·2003· 95 cited
5H-8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-Targeting agents: influence of structure on the ternary cleavable complex formation
Bioorganic & Medicinal Chemistry Letters·2003· 12 cited
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Frequent Co-authors

Leroy F. Liu(14), Angela Liu(12), Edmond J. LaVoie(12), Nai Zhou(9), Tsai‐Kun Li(7), Sudhir Singh(6), Shejin Zhu(4), Gang Lu(3), Gilles Carmel(3), Abhijit Ray(3), Jinming Yang(3), George W. Muller(3), Hon‐Wah Man(3), John R. Coombs(3), Mary E. Matyskiela(2), Takumi Ito(2), Barbra Pagarigan(2), Chin-Chun Lu(2), Karen Miller(2), Wei Fang(2)