Mary E. Matyskiela

Bristol-Myers Squibb (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.6kcitations50works3.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(34), Protein Degradation and Inhibitors(22), Multiple Myeloma Research and Treatments(18), Peptidase Inhibition and Analysis(12), Endoplasmic Reticulum Stress and Disease(8)

Publications50 total

Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760
Journal of Medicinal Chemistry·2025· 3 cited
Supplementary Table S1 from Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
2023Open Access
Supplementary Table S1 from Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
2023Open Access
Data from Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
2023Open Access
Supplementary Data from Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
2023Open Access
Supplementary Data from Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
2023Open Access
Data from Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
2023Open Access
Molecular glue CELMoD compounds are regulators of cereblon conformation
Science·2022· 176 citedOpen Access
Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation
2022· 4 citedOpen Access
Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies
Blood Cancer Discovery·2021· 42 citedOpen Access
Profiling CELMoD-Mediated Degradation of Cereblon Neosubstrates
Methods in molecular biology·2021· 4 cited
Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons
ACS Chemical Biology·2020· 41 cited
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells
Blood·2020· 208 citedOpen Access
New Activities of CELMoDs, Cereblon E3 Ligase-modulating Drugs
2020
Cereblon in complex with DDB1, CC-90009, and GSPT1
2020
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex
Nature Structural & Molecular Biology·2020· 97 cited
Proteasome Conformational Regulation of Substrate Engagement and Degradation
Biophysical Journal·2020Open Access
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation
eLife·2019· 39 citedOpen Access
CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells
Blood·2019· 21 cited
Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality
ACS Medicinal Chemistry Letters·2019· 67 citedOpen Access
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Frequent Co-authors

Philip P. Chamberlain(25), Gabriel C. Lander(16), Thomas Clayton(15), Mark Rolfe(13), Gang Lu(11), Andreas Martin(11), Chin-Chun Lu(8), Brian E. Cathers(8), Barbra Pagarigan(7), Aline Renneville(7), Jessica A. Gasser(7), Daniel E. Grinshpun(7), Pierre M. Jean Beltran(7), Namrata D. Udeshi(7), Kaushik Viswanathan(7), Andrew A. Guirguis(7), Rob S. Sellar(7), Sophie Cotteret(7), Christophe Marzac(7), Véronique Saada(7)