Gilles Carmel

Hexcel (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index5.6kcitations27works0.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(8), Protein Degradation and Inhibitors(8), Multiple Myeloma Research and Treatments(7), Enzyme Structure and Function(5), Bacterial Genetics and Biotechnology(4)

Publications27 total

Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
Cancer Research·2017
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos
Journal of Medicinal Chemistry·2017· 284 citedOpen Access
Protein Degradation via CRL4<sup>CRBN</sup> Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Journal of Medicinal Chemistry·2017· 76 cited
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
Nature·2016· 629 cited
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Nature Structural & Molecular Biology·2014· 499 cited
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
British Journal of Haematology·2013· 102 citedOpen Access
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
Leukemia·2012· 785 citedOpen Access
Direct Binding with Cereblon Mediates the Antiproliferative and Immunomodulatory Action of Lenalidomide and Pomalidomide
Blood·2011· 5 cited
Identification and Characterization of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase
Antimicrobial Agents and Chemotherapy·2004· 66 citedOpen Access
Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·2002· 26 cited
Structure of the Unliganded cAMP-Dependent Protein Kinase Catalytic Subunit from Saccharomyces cerevisiae
Archives of Biochemistry and Biophysics·2001· 15 cited
<i>Helicobacter pylori</i>Physiology Predicted from Genomic Comparison of Two Strains
Microbiology and Molecular Biology Reviews·1999· 188 citedOpen Access
Erratum: Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
Nature·1999· 7 citedOpen Access
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
Nature·1999· 1.9k cited
The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology
Journal of Biological Chemistry·1996· 395 citedOpen Access
Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors.
Proceedings of the National Academy of Sciences·1996· 47 citedOpen Access
Crystal structure of casein kinase-1, a phosphate-directed protein kinase.
The EMBO Journal·1995· 197 citedOpen Access
Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity.
Molecular Biology of the Cell·1994· 69 citedOpen Access
Cytoplasmic forms of fission yeast casein kinase-1 associate primarily with the particulate fraction of the cell.
Journal of Biological Chemistry·1994· 35 citedOpen Access
Expression, purification, crystallization, and preliminary x-ray analysis of casein kinase-1 from Schizosaccharomyces pombe.
Journal of Biological Chemistry·1994· 57 citedOpen Access
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Frequent Co-authors

Jeff Kuret(9), Brian E. Cathers(7), Antonia Lopez‐Girona(6), Karen Miller(5), Richard A. Alm(4), Donald T. Moir(4), Peter J. Tummino(4), Takumi Ito(4), Emily Rychak(4), Svetlana Gaidarova(4), Peter Schäfer(4), Hiroshi Handa(4), Gang Lu(4), Barbra Pagarigan(4), Mariko Riley(4), Thomas O. Daniel(4), Philip P. Chamberlain(4), Losee L. Ling(3), Eric D. Brown(3), P. Doig(3)