Thomas O. Daniel

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index9.9kcitations72works0.02yr avg
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Research Topics

Angiogenesis and VEGF in Cancer(14), Multiple Myeloma Research and Treatments(10), Ubiquitin and proteasome pathways(9), Protein Degradation and Inhibitors(9), Protein Kinase Regulation and GTPase Signaling(8)

Publications72 total

Synthesis And Characterization Of Optical And Structural Properties Of Inorganic And Green Leaf Doped Sno Thin Films Deposited Using Spray Pyrolysis
Global Journal of Pure and Applied Science·2024Open Access
Energy and Fuels: Structural and Optical Characterization of Cu2ZnSnS4 Solar Absorber Layer for Photovoltaic Application Using SILAR Method
Green energy and technology·2022· 1 cited
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma
Journal of Medicinal Chemistry·2020· 205 citedOpen Access
Discovery of CRBNE3 Ligase Modulator CC-92480 forthe Treatment of Relapsed and Refractory Multiple Myeloma
Figshare·2020Open Access
CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)
Blood·2019· 25 cited
Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
Cancer Research·2017
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos
Journal of Medicinal Chemistry·2017· 284 citedOpen Access
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
Nature·2016· 629 cited
Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma
British Journal of Haematology·2016· 56 citedOpen Access
Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity
Blood·2015· 1 cited
CC-122 Exhibits Potent Anti-Lymphoma Activity in Combination with Obinutuzumab through Cell Autonomous and Antibody Dependent Cell Mediated Cytotoxicity
Blood·2015· 3 cited
RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1
Blood·2015· 39 citedOpen Access
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Blood·2015· 198 citedOpen Access
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Nature Structural & Molecular Biology·2014· 499 cited
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Nature Medicine·2014· 270 citedOpen Access
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate <scp>T</scp> cells by inducing degradation of <scp>T</scp> cell repressors <scp>I</scp> karos and <scp>A</scp> iolos via modulation of the <scp>E</scp> 3 ubiquitin ligase complex <scp>CRL</scp> 4 <scp> <sup>CRBN</sup> </scp>
British Journal of Haematology·2013· 613 citedOpen Access
RAP-011 Efficiently Rescues Erythropoiesis In Zebrafish Models Of Diamond Blackfan Anemia
Blood·2013· 2 cited
The recovery of latent text from thermal paper using a simple iodine treatment procedure
Forensic Science International·2011· 15 cited
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
Bioorganic & Medicinal Chemistry Letters·2011· 62 citedOpen Access
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
DSpace@MIT (Massachusetts Institute of Technology)·2011Open Access
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Frequent Co-authors

Douglas Pat Cerretti(7), Takamune Takahashi(6), Brian E. Cathers(5), Antonia Lopez‐Girona(5), Rajesh Chopra(5), Hua Liu(5), Dale R. Abrahamson(5), L T Williams(4), Uyen Huynh‐Do(4), Keiko Takahashi(4), Gang Lu(3), Takumi Ito(3), Barbra Pagarigan(3), Karen Miller(3), Gilles Carmel(3), Mariko Riley(3), Hiroshi Handa(3), James Carmichael(3), Philip P. Chamberlain(3), Anita K. Gandhi(3)