Laiq Chaudry

Medicine · Health Sciences

10h-index462citations15works0.02yr avg
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Research Topics

Blood Coagulation and Thrombosis Mechanisms(7), Atrial Fibrillation Management and Outcomes(5), Cytokine Signaling Pathways and Interactions(3), Coagulation, Bradykinin, Polyphosphates, and Angioedema(3), Growth Hormone and Insulin-like Growth Factors(2)

Publications15 total

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor
Antioxidants and Redox Signaling·2015· 187 citedOpen Access
The development of irreversible ITK inhibitors as a potential new treatment for severe asthma
2014
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
2013
Discovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP Pocket
Journal of Biological Chemistry·2013· 32 citedOpen Access
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 9 citedOpen Access
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
Bioorganic & Medicinal Chemistry Letters·2009· 12 cited
Antithrombotic Potential of GW813893: A Novel, Orally Active, Active-site Directed Factor Xa Inhibitor
Journal of Cardiovascular Pharmacology·2008· 17 cited
Factor Xa Inhibitors:  S1 Binding Interactions of a Series of <i>N</i>-{(<i>3S</i>)-1-[(<i>1S</i>)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides
Journal of Medicinal Chemistry·2007· 49 citedOpen Access
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 30 citedOpen Access
General considerations for proteolytic cascades
Biochemical Society Transactions·2004· 18 cited
Release of arachidonic acid and the effects of corticosteroids on steroidogenesis in rat testis Leydig cells
The Journal of Steroid Biochemistry and Molecular Biology·1991· 65 cited
Incorporation of arachidonic acid and its release from rat Leydig cells
Biochemical Society Transactions·1989· 4 cited
IMMUNOREACTIVE HUMAN CHORIONIC GONADOTROPHIN FROM THE CYST FLUID AND CSF OF PATIENTS WITH CRANIOPHARYNGIOMA
Clinical Endocrinology·1988· 17 cited
Hyperbaric liver dysfunction in saturation divers.
PubMed·1985· 9 cited

Frequent Co-authors

Chuen Chan(6), David Brown(6), Nigel S. Watson(6), John D. Harling(6), Cynthia L. Burns-Kurtis(5), M.A. Convery(5), Angela Patikis(5), Anthony J. Pateman(5), Stefan Senger(5), John R. Toomey(5), Robert J. Young(5), Savvas Kleanthous(4), Ping Zhou(4), B.A. Cooke(3), Matthew Campbell(3), Champa Patel(3), Gita P. Shah(3), Angela M. Deakin(3), Rachel L. Grimley(3), Nick Barton(3)