Nigel S. Watson

University of Gloucestershire — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.1kcitations76works1.32yr avg
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Research Topics

Plant biochemistry and biosynthesis(23), Microbial Natural Products and Biosynthesis(16), Blood Coagulation and Thrombosis Mechanisms(15), Natural product bioactivities and synthesis(15), Atrial Fibrillation Management and Outcomes(14)

Publications76 total

The Challenges of Agentic AI Safety
Oxford University Press eBooks·2025· 4 cited
From Black Box to Open Book: An Emerging Transparency Imperative in Generative AI Codebases
2025
Abstract 1917 A solution NMR based approach to characterizing ASCC2-CUE specificity for K63-linked polyubiquitin chains in DNA alkylation damage repair
Journal of Biological Chemistry·2025Open Access
Factor Xa complex with GTC000441
2015
Factor Xa complex with GTC000401
2015
Factor Xa complex with GTC000398
2015
Factor Xa complex with GTC000422
2015
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 13 citedOpen Access
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Bioorganic & Medicinal Chemistry Letters·2011· 9 citedOpen Access
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
Bioorganic & Medicinal Chemistry Letters·2009· 12 cited
Antithrombotic Potential of GW813893: A Novel, Orally Active, Active-site Directed Factor Xa Inhibitor
Journal of Cardiovascular Pharmacology·2008· 17 cited
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs
Bioorganic & Medicinal Chemistry Letters·2007· 29 citedOpen Access
Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Bioorganic & Medicinal Chemistry Letters·2007· 23 citedOpen Access
Selective and dual action orally active inhibitors of thrombin and factor Xa
Bioorganic & Medicinal Chemistry Letters·2007· 22 citedOpen Access
Factor Xa Inhibitors:  S1 Binding Interactions of a Series of <i>N</i>-{(<i>3S</i>)-1-[(<i>1S</i>)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides
Journal of Medicinal Chemistry·2007· 49 citedOpen Access
Human Thrombin Hirugen Inhibitor complex
2007
Sulfonamide-related conformational effects and their importance in structure-based design
Bioorganic & Medicinal Chemistry Letters·2007· 31 citedOpen Access
Design and Synthesis of Orally Active Pyrrolidin‐2‐one‐Based Factor Xa Inhibitor.
ChemInform·2006· 1 cited
Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs
Bioorganic & Medicinal Chemistry Letters·2006· 40 citedOpen Access
Arylsulfonamides: A study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 26 citedOpen Access
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Frequent Co-authors

Panayiotis A. Procopiou(21), Chuen Chan(12), M.A. Convery(11), Stefan Senger(11), David Brown(10), Robert J. Young(10), Cynthia L. Burns-Kurtis(9), Anthony J. Pateman(9), Julie L. Hutson(8), Angela Patikis(8), Gita P. Shah(8), John R. Toomey(8), Henry A. Kelly(7), Savvas Kleanthous(7), Ping Zhou(7), Graham G. A. Inglis(7), Barry C. Ross(6), Matthew Campbell(6), Laiq Chaudry(6), Michael Lester(6)