Brian A. McKittrick

Drew University — United States

Computer Science · Physical Sciences

27h-index1.9kcitations80works8.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Computational Drug Discovery Methods(13), Receptor Mechanisms and Signaling(13), Chemical Synthesis and Analysis(11), Cholinesterase and Neurodegenerative Diseases(9), Alzheimer's disease research and treatments(8)

Publications80 total

History and Prospects of Drug Discovery and Development Collaboration between Industry and Academia
Journal of Natural Products·2024· 8 cited
Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA
ACS Omega·2023· 12 citedOpen Access
CCDC 2018403: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Unprecedented Reversal of Regioselectivity during Methanolysis and an Interception of Curtius Rearrangement
European Journal of Organic Chemistry·2021
Generation of Leads for γ-Secretase Modulation
Journal of Medicinal Chemistry·2020· 10 citedOpen Access
FERRY: access control and quota management service
EPJ Web of Conferences·2019· 2 citedOpen Access
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates
Journal of Medicinal Chemistry·2016· 41 citedOpen Access
Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors
Bioorganic & Medicinal Chemistry Letters·2015· 9 citedOpen Access
Discovery of potent iminoheterocycle BACE1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2014· 20 citedOpen Access
Biased Ligand Modulation of Seven Transmembrane Receptors (7TMRs): Functional Implications for Drug Discovery
Journal of Medicinal Chemistry·2014· 54 citedOpen Access
Identification of 2-aminooxazole amides as acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy
Bioorganic & Medicinal Chemistry Letters·2013· 11 citedOpen Access
Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation
Journal of Medicinal Chemistry·2012· 56 citedOpen Access
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction
ACS Medicinal Chemistry Letters·2012· 98 citedOpen Access
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor
Bioorganic & Medicinal Chemistry Letters·2012· 151 citedOpen Access
SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist
Bioorganic & Medicinal Chemistry Letters·2011· 14 citedOpen Access
The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia
Bioorganic & Medicinal Chemistry Letters·2011· 32 citedOpen Access
The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia
2011
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia
ACS Medicinal Chemistry Letters·2011· 27 citedOpen Access
Discovery of a Potent Thiadiazole Class of Histamine H<sub>3</sub> Receptor Antagonist for the Treatment of Diabetes
ACS Medicinal Chemistry Letters·2011· 23 citedOpen Access
Stereoselective synthesis of C-6 hydroxy tricyclic sulfone as a γ-secretase inhibitor
Tetrahedron Letters·2011· 7 cited
page 1 of 4Next →

Frequent Co-authors

William J. Greenlee(18), Zhaoning Zhu(14), Michael Czarniecki(12), Andrew W. Stamford(11), Eric M. Parker(9), Vincent Madison(8), Johannes Voigt(8), Peter Orth(8), Haiqun Tang(8), Corey Strickland(7), Robert Mazzola(7), Jing Su(7), Elizabeth M. Smith(6), Matthew Kennedy(6), Reshma Kuvelkar(6), Lynn A. Hyde(6), Leonard Favreau(6), Ahmad Fawzi(6), Duane A. Burnett(6), John W. Clader(6)