Eric M. Parker

Secretaría Nacional de Ciencia, Tecnología e Innovación — PA

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index7.3kcitations147works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(45), Alzheimer's disease research and treatments(42), Computational Drug Discovery Methods(32), Cholinesterase and Neurodegenerative Diseases(29), Neuropeptides and Animal Physiology(23)

Publications147 total

Damping Devices for Seismic Protection of Substation Equipment
2022
Amino Acid Analyses of Hayabusa2 Samples via Liquid Chromatography with Fluorescence Detection and High-Resolution Mass Spectrometry
Goldschmidt2022 abstracts·2022· 1 citedOpen Access
Survey-based Exploratory Factor Analysis of Building-Occupant Behavior Interaction: A Case Study in Panama
Proceedings of the 20th LACCEI International Multi-Conference for Engineering, Education and Technology: “Education, Research and Leadership in Post-pandemic Engineering: Resilient, Inclusive and Sustainable Actions”·2022Open Access
BACE1 – but not BACE2 – function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice
2021· 1 citedOpen Access
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors
Bioorganic & Medicinal Chemistry Letters·2021· 4 citedOpen Access
Evaluation of particle filtration efficiency of commercially available materials for homemade face mask usage
Aerosol Science and Technology·2021· 36 citedOpen Access
Generation of Leads for γ-Secretase Modulation
Journal of Medicinal Chemistry·2020· 10 citedOpen Access
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety
Journal of Medicinal Chemistry·2018· 16 citedOpen Access
Informing Decisions in Discovery and Early Development Research Through Quantitative and Translational Modeling
Methods and principles in medicinal chemistry·2018
Promoting Positive Top-Line and Bottom-Line Growth for Clients
The Hearing Journal·2018
Bioprinted 3D Primary Human Intestinal Tissues Model Aspects of Native Physiology and ADME/Tox Functions
iScience·2018· 150 citedOpen Access
Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators
ACS Medicinal Chemistry Letters·2017· 13 citedOpen Access
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage
Journal of Alzheimer s Disease·2017· 27 citedOpen Access
[P1–108]: SYSTEMS PHARMACOLOGY ANALYSIS OF THE Aβ OLIGOMER RESPONSE FOLLOWING BACE1 INHIBITION: EVIDENCE FOR SECOND‐ORDER Aβ42 OLIGOMERIZATION
Alzheimer s & Dementia·2017
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
Molecular Neurodegeneration·2017· 148 citedOpen Access
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Journal of Medicinal Chemistry·2017· 141 citedOpen Access
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
Journal of Medicinal Chemistry·2016· 161 citedOpen Access
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients
Science Translational Medicine·2016· 407 cited
Substituted 4-morpholine N -arylsulfonamides as γ-secretase inhibitors
European Journal of Medicinal Chemistry·2016· 13 citedOpen Access
P1‐107: Is the Peripheral Sink Hypothesis Physiologically Feasible? Evidence from Model‐Based Assessment of the Amyloid Pathway
Alzheimer s & Dementia·2016· 2 cited
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Frequent Co-authors

Andrew W. Stamford(13), Lynn A. Hyde(13), Matthew Kennedy(12), Johannes Voigt(10), Reshma Kuvelkar(9), Guy A. Higgins(8), Jared N. Cumming(8), Robert A. Hodgson(8), Corey Strickland(8), William J. Greenlee(7), Lixin Song(7), Geoffrey B. Varty(6), Leonard Favreau(6), Kathleen Cox(5), Jack D. Scott(5), John C. Hunter(5), Ulrich Iserloh(5), Yusheng Wu(5), Zhaoning Zhu(5), Brian A. McKittrick(5)