Lien Van Hoecke

Ghent University Hospital — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.7kcitations75works5.52yr avg
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Research Topics

RNA Interference and Gene Delivery(15), Immunotherapy and Immune Responses(13), Extracellular vesicles in disease(12), Neuroinflammation and Neurodegeneration Mechanisms(12), Liver Disease and Transplantation(11)

Publications75 total

Efficient delivery of gene editors using intein-engineered virus-like particles
2026Open Access
Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
Nature Neuroscience·2026· 1 citedOpen Access
Decoding brain border immunity to enable future therapeutic avenues
Trends in Immunology·2026Open Access
Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis
Fluids and Barriers of the CNS·2025Open Access
Mesenchymal stromal cell extracellular vesicles as immune modulators and drug carriers in neurodegenerative disorders
Trends in Neurosciences·2025· 4 citedOpen Access
Glial-specific and inducible full body C3 deficiency does not affect amyloid pathology in the AppNL-G-F mouse model of Alzheimer’s disease
2025· 2 citedOpen Access
The gut–brain axis in Alzheimer’s disease is shaped by commensal gut microbiota derived extracellular vesicles
Gut Microbes·2025· 7 citedOpen Access
Modeling epithelial and endothelial cell tropism for SARS-CoV-2 through restricted transgenic hACE2 expression in mice
2025Open Access
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Nature Communications·2025· 46 citedOpen Access
Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies
Neural Regeneration Research·2024· 6 citedOpen Access
Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis
Journal of Extracellular Biology·2024· 4 citedOpen Access
IL-34 empowers regulatory T cells with novel non-canonical function to safeguard brain barrier integrity during neuro-inflammation
2024Open Access
Newly discovered base barrier cells provide compartmentalization of choroid plexus, brain and CSF
2024· 6 cited
A new MVA ancestor-derived oncolytic vaccinia virus induces immunogenic tumor cell death and robust antitumor immune responses
Molecular Therapy·2024· 10 citedOpen Access
Superficial Serratus Anterior Plane Block for Minimal Invasive Cardiac Surgery: a single-center randomized controlled trial
Acta Anaesthesiologica Belgica·2024· 1 citedOpen Access
Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer’s disease
Acta Neuropathologica Communications·2024· 1 citedOpen Access
The Spreading and Effects of Human Recombinant α-Synuclein Preformed Fibrils in the Cerebrospinal Fluid of Mice
eNeuro·2024· 5 citedOpen Access
An immunological puzzle: The adaptive immune system fuels Alzheimer’s disease pathology
Brain Behavior and Immunity·2023· 6 citedOpen Access
Limitations of PLX3397 as a microglial investigational tool: peripheral and off-target effects dictate the response to inflammation
Frontiers in Immunology·2023· 27 citedOpen Access
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
2023· 3 citedOpen Access
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Frequent Co-authors

Roosmarijn E. Vandenbroucke(21), Xavier Saelens(20), Elien Van Wonterghem(14), Junhua Xie(13), Griet Van Imschoot(12), Kenny Roose(11), Wouter Claeys(9), Johan Grooten(8), Stefaan De Koker(8), Bert Schepens(7), Jonas Castelein(7), Ans De Beuckelaer(6), Sandra Van Lint(5), Anja Geerts(5), Christophe Van Steenkiste(5), Bruno G. De Geest(4), Thomas Naessens(4), Muriel Smet(4), Niek N. Sanders(4), Samir EL Andaloussi(4)