Niek N. Sanders

Ghent University — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

58h-index11.9kcitations221works6.82yr avg
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Research Topics

RNA Interference and Gene Delivery(103), Advanced biosensing and bioanalysis techniques(53), Immunotherapy and Immune Responses(44), Virus-based gene therapy research(26), Immune Response and Inflammation(21)

Publications221 total

Influence of the administration route and dose on the expression and antibody responses of a reporter and avian influenza self-amplifying mRNA vaccine in poultry
Veterinary Quarterly·2026Open Access
Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines
Nature Communications·2025Open Access
Overcoming cold chain challenges: Cryoprotection of self-amplifying mRNA polyplexes for long-term storage at ambient temperature
Journal of Controlled Release·2025Open Access
Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye
Journal of Controlled Release·2025· 8 citedOpen Access
Admixing of mRNA with Pre‐Formed Lipid Nanoparticles Containing a Slightly‐Cationic Ionizable Lipid Allows for Efficient mRNA Transfection In Vitro and In Vivo
Advanced Healthcare Materials·2025· 3 cited
Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIs
Drug Delivery and Translational Research·2025Open Access
Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the p <i>K</i> <sub>a</sub> of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo
Angewandte Chemie·2025· 1 cited
Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the p <i>K</i> <sub>a</sub> of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo
Angewandte Chemie International Edition·2025· 4 citedOpen Access
Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIs
2025· 1 citedOpen Access
The past, present, and future of RNA vaccines
Molecular Therapy·2025· 1 cited
Cyclic Poly(2-methyl-2-oxazoline)-Lipid Conjugates Are Good Alternatives to Poly(ethylene glycol)-Lipids for Lipid Nanoparticle mRNA Formulation
Biomacromolecules·2025· 6 cited
Evaluation of possible administration routes of a self-amplifying mRNA vaccine against influenza A virus in poultry
Ghent University Academic Bibliography (Ghent University)·2025
A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity
Angewandte Chemie International Edition·2024· 8 citedOpen Access
A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity
Angewandte Chemie·2024· 2 cited
Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation
ACS Nano·2024· 19 citedOpen Access
PH‐Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2‐Propionic‐3‐Methyl‐maleic Anhydrides with Cholesteryl End Groups
Advanced Healthcare Materials·2024· 4 citedOpen Access
Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza
npj Vaccines·2024· 23 citedOpen Access
CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity
Biomaterials·2024· 10 citedOpen Access
Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
Breast Cancer Research·2024· 5 citedOpen Access
Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery
Advanced Functional Materials·2024· 26 citedOpen Access
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Frequent Co-authors

Stefaan C. De Smedt(34), Joseph Demeester(16), Roosmarijn E. Vandenbroucke(9), Kevin Braeckmans(9), Ine Lentacker(8), Bruno G. De Geest(7), Kevin Buyens(6), Zifu Zhong(5), Séan Mc Cafferty(4), Liesbeth Peeters(4), Jo Demeester(4), Oliwia Andries(3), J. Demeester(3), Sebastian Ulbert(3), Francis Combes(3), Stefan Lienenklaus(3), Koen Raemdonck(3), Katrien Remaut(3), Olivier De Wever(3), Wim Van Den Broeck(3)