R. Keith Humphries

BC Cancer Agency — Canada

Medicine · Health Sciences

98h-index30.6kcitations429works0.02yr avg
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Research Topics

Acute Myeloid Leukemia Research(104), Hematopoietic Stem Cell Transplantation(82), Virus-based gene therapy research(64), RNA Interference and Gene Delivery(50), Epigenetics and DNA Methylation(46)

Publications429 total

Transcriptional control of leukemogenesis by the chromatin reader SGF29
Blood·2023· 15 citedOpen Access
Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression
Nature Communications·2023· 16 citedOpen Access
Supplementary Data from CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
2023Open Access
Data from CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
2023Open Access
Supplementary Data from CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
2023Open Access
Data from CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
2023Open Access
High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of <i>HOX/MEIS</i> Activation in Acute Myeloid Leukemia
2022· 1 citedOpen Access
Abstract PR004: High-density CRISPR screens reveal mechanisms of chromatin regulation of stemness networks in acute myeloid leukemia
Cancer Research·2022
<i>Meis1</i> Establishes the Pre-Hemogenic Endothelial State Prior to <i>Runx1</i> Expression
Blood·2022· 1 cited
Elucidating the importance and regulation of key enhancers for human MEIS1 expression
Leukemia·2022· 13 citedOpen Access
3030 – THE EPIGENETIC REGULATOR LANDSCAPE OF STEMNESS NETWORKS IN ACUTE MYELOID LEUKEMIA
Experimental Hematology·2022
Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression
Blood·2021
Correction: Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
Leukemia·2021Open Access
Fond Memories of Arthur W. Nienhuis, 1941–2021
Experimental Hematology·2021
Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma
Haematologica·2021· 4 citedOpen Access
High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of <i>Hox/Meis</i> Gene Expression in Acute Myeloid Leukemia
Blood·2020· 3 cited
The methyltransferase G9a regulates HoxA9-dependent transcription in AML
UNC Libraries·2020· 7 citedOpen Access
Genetic Manipulation of Human Marrow: Gene Transfer Using Retroviruses
2020
Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
Leukemia·2020· 20 citedOpen Access
Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression
Haematologica·2020· 2 citedOpen Access
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Frequent Co-authors

Guy Sauvageau(14), Connie J. Eaves(14), H. Jeffrey Lawrence(8), Corey Largman(7), Gerald Krystal(6), Cheryl D. Helgason(6), Florian Kuchenbauer(5), Marco A. Marra(5), Donna E. Hogge(5), Peter M. Lansdorp(5), Ryan D. Morin(4), Jacqueline E. Damen(4), Unnur Þorsteinsdóttir(4), Allen Delaney(3), Martin Hirst(3), Jennifer Antonchuk(3), Bob Argiropoulos(3), Patricia M. Rosten(3), Robert Pawliuk(3), Irving M. London(3)