Zoë A. Hughes

Washington University in St. Louis — United States

Neuroscience · Life Sciences

35h-index4.2kcitations87works1.72yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(29), Neurotransmitter Receptor Influence on Behavior(24), Receptor Mechanisms and Signaling(17), Treatment of Major Depression(10), Phosphodiesterase function and regulation(9)

Publications85 total

Constraints on axionlike particles from VERITAS observations of a flaring radio galaxy in the Perseus cluster
Physical review. D/Physical review. D.·2025Open Access
A novel psychedelic 5-HT <sub>2A</sub> receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer
Journal of Psychopharmacology·2025· 1 cited
Low (micro)doses of 2,5-dimethoxy-4-propylamphetamine (DOPR) increase effortful motivation in low-performing mice
Neuropharmacology·2025· 1 cited
The ChaSE project: Chalk Sea Ecosystems and Cretaceous environmental change in the Chalk Group of the United Kingdom
Abstracts with programs - Geological Society of America·2025
GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents
Neuropsychopharmacology·2024· 10 citedOpen Access
Pharmacokinetic, pharmacodynamic and subjective and effects of the novel 5-HT2A receptor agonist GM-2505 in healthy volunteers
Neuroscience Applied·2024Open Access
Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
Journal of Neuroinflammation·2023· 13 citedOpen Access
First-in-Human Evaluation of<sup>18</sup>F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B
Journal of Nuclear Medicine·2022· 13 citedOpen Access
Translational Pharmacology of PRAX-944, a Novel T-type Calcium Channel Blocker for the Treatment of Essential Tremor (S32.009)
Neurology·2022
Translational Pharmacology of <scp>PRAX</scp>‐944, a Novel T‐Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor
Movement Disorders·2022· 17 citedOpen Access
The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers
Epilepsia·2022· 27 citedOpen Access
OUTCOME MEASURES
Neuromuscular Disorders·2021
Monkey, rat, and first in human evaluation of [18F]PF-06445974, a PET radioligand that preferentially labels phosphodiesterase 4B
2021
PRAX-114 is a Novel Extrasynaptic GABA-A Receptor Preferring Positive Allosteric Modulator With a Wide Separation Between a Translational Biomarker Signature Associated With Antidepressant-Like Activity, and Sedative Effects
Biological Psychiatry·2021· 3 cited
PRAX-114 Produces Robust Increases in EEG Beta Frequency Power, a Translational Biomarker of GABA-A Receptor Modulation, Without Dose-Limiting Sedation
Biological Psychiatry·2021
Discovery of the First Orally Available, Selective K<sub>Na</sub>1.1 Inhibitor: <i>In Vitro</i> and <i>In Vivo</i> Activity of an Oxadiazole Series
ACS Medicinal Chemistry Letters·2021· 49 citedOpen Access
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index
Biological Psychiatry Cognitive Neuroscience and Neuroimaging·2021· 29 citedOpen Access
The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges
Journal of Psychopharmacology·2018· 10 cited
Verbal working memory and functional large-scale networks in schizophrenia
Psychiatry Research Neuroimaging·2017· 11 citedOpen Access
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Journal of Medicinal Chemistry·2017· 36 cited
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Frequent Co-authors

Sharon Rosenzweig‐Lipson(11), Lee E. Schechter(9), Lee A. Dawson(9), Robert H. Ring(8), Nicholas J. Brandon(7), Stacey J. Sukoff Rizzo(6), John Dunlop(6), Jason M. Dwyer(5), Sarah J. Neal Webb(4), Chad E. Beyer(4), Karen L. Marquis(4), Meiyi Zhang(4), S. Clare Stanford(4), Jessica E. Malberg(3), Radka Graf(3), Sheree F. Logue(3), Thomas A. Comery(3), Mark L. Day(3), Zia Ur Rahman(3), Claire S Shilliam(3)