Lee E. Schechter

Pfizer (United States) — United States

Neuroscience · Life Sciences

46h-index6.6kcitations117works0.02yr avg
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Research Topics

Neurotransmitter Receptor Influence on Behavior(44), Receptor Mechanisms and Signaling(32), Neuroscience and Neuropharmacology Research(29), Synthesis and Biological Evaluation(14), Nicotinic Acetylcholine Receptors Study(12)

Publications117 total

The effects of systemic and local microinjection into the central nervous system of the selective serotonin 5-HT6 receptor agonist WAY-208466 on sleep and wakefulness in the rat
Behavioural Brain Research·2013· 19 cited
5‐HT<sub>2C</sub>and 5‐HT<sub>6</sub>Receptor Targeted Emerging Approaches in Schizophrenia
2012· 1 cited
Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
Neuropharmacology·2012· 85 cited
Concomitant blockade of 5-HT1A receptor and 5-HT transporter: Use of the Hunter Serotonin Toxicity Criteria in a clinical pharmacology study
European Neuropsychopharmacology·2011· 6 cited
Characterization of Vabicaserin (SCA-136), a Selective 5-Hydroxytryptamine 2C Receptor Agonist
Journal of Pharmacology and Experimental Therapeutics·2011· 49 cited
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
Bioorganic & Medicinal Chemistry·2010· 23 citedOpen Access
5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists
Journal of Medicinal Chemistry·2010· 66 citedOpen Access
Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation
Psychopharmacology·2010· 28 cited
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats
Psychopharmacology·2010· 82 cited
5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT<sub>6</sub> Receptor Antagonists
Journal of Medicinal Chemistry·2010· 22 citedOpen Access
Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression
Pharmacology Biochemistry and Behavior·2010· 16 cited
3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators
Bioorganic & Medicinal Chemistry Letters·2010· 22 citedOpen Access
Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity
Bioorganic & Medicinal Chemistry Letters·2010· 29 citedOpen Access
Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective α2A-adrenoceptor antagonism
The International Journal of Neuropsychopharmacology·2010· 26 citedOpen Access
Synthesis and structure–activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter
Bioorganic & Medicinal Chemistry Letters·2009· 16 citedOpen Access
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands
Bioorganic & Medicinal Chemistry Letters·2009· 11 citedOpen Access
Synthesis, Potency, and in Vivo Evaluation of 2-Piperazin-1-ylquinoline Analogues as Dual Serotonin Reuptake Inhibitors and Serotonin 5-HT<sub>1A</sub>Receptor Antagonists
Journal of Medicinal Chemistry·2009· 17 citedOpen Access
Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
Neuropharmacology·2009· 145 cited
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT6 agonists
Bioorganic & Medicinal Chemistry·2009· 21 citedOpen Access
5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats
The International Journal of Neuropsychopharmacology·2009· 25 cited
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Frequent Co-authors

Sharon Rosenzweig‐Lipson(18), Deborah L. Smith(11), Robert H. Ring(9), Jessica E. Malberg(8), Stacey J. Sukoff Rizzo(8), Chad E. Beyer(8), Zoë A. Hughes(7), Brian J. Platt(7), Lee A. Dawson(6), Terrance H. Andree(5), Irwin Lucki(5), Stanley Nawoschik(5), Jason M. Dwyer(5), M. Hamon(5), H. Gozlan(5), Zia Ur Rahman(4), Michael A. Olsen(4), Derek C. Cole(4), Ronald C. Bernotas(4), Hossein Mazandarani(4)