John R. Somoza

Gilead Sciences (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.8kcitations73works0.62yr avg
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Research Topics

Protease and Inhibitor Mechanisms(13), HIV/AIDS drug development and treatment(11), Biochemical and Molecular Research(10), Enzyme Structure and Function(8), Bone Metabolism and Diseases(8)

Publications73 total

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis
Journal of Medicinal Chemistry·2025· 3 citedOpen Access
HIV Capsid Hexamer bound to Compound 12
2025
HIV Capsid Hexamer bound to Compound 40
2025
HIV Capsid Hexamer bound to Compound 24
2025
HIV Capsid Hexamer bound to Compound 6
2025
Clinical targeting of HIV capsid protein with a long-acting small molecule
Nature·2020· 394 citedOpen Access
Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207
2019
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor
Journal of Medicinal Chemistry·2018· 61 citedOpen Access
Selective PI3K beta inhibitor bound to PI3K delta
2018
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)
Bioorganic & Medicinal Chemistry Letters·2017· 10 cited
The structure of human CamKII with bound inhibitor
2017
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability
Journal of Medicinal Chemistry·2016· 44 citedOpen Access
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors
Journal of Medicinal Chemistry·2016· 47 citedOpen Access
The crystal structure of PI3Kdelta with compound 32
2016
Functional Label-Free Assays for Characterizing the <i>in Vitro</i> Mechanism of Action of Small Molecule Modulators of Capsid Assembly
Biochemistry·2015· 10 cited
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ
Journal of Biological Chemistry·2015· 153 citedOpen Access
Idelalisib bound to the p110 subunit of PI3K delta
2014
PP005-SUN EFFECT OF GOS/FOS ON GROWTH, FECAL LACTIC ACID BACTERIA AND BONE CHARACTERISTICS IN AN EXPERIMENTAL MODEL IN RATS
Clinical Nutrition Supplements·2012
3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2011· 17 cited
3-heterocyclyl quinolone bound to HCV NS5B
2011
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Frequent Co-authors

Mary E. McGrath(13), James T. Palmer(8), Joseph D. Ho(7), Armando G. Villaseñor(7), James W. Janc(7), David Koditek(6), Latesh Lad(6), B.A. Katz(5), Robert J. Fletterick(5), Paul A. Sprengeler(5), Kyle Mortara(5), H. Szöke(5), A. Szöke(5), Giuseppe A. Papalia(4), Ching C. Wang(4), Michael J. Green(4), Christine Luong(3), Joseph J. Buggy(3), Erik Verner(3), Winston C. Tse(3)