B.A. Katz

Medicine · Health Sciences

30h-index3.8kcitations91works0.02yr avg
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Research Topics

Blood Coagulation and Thrombosis Mechanisms(17), Coagulation, Bradykinin, Polyphosphates, and Angioedema(17), Protease and Inhibitor Mechanisms(13), Click Chemistry and Applications(10), Peptidase Inhibition and Analysis(10)

Publications91 total

Small Molecule Inhibitors of Plasma Kallikrein.
ChemInform·2006· 1 cited
Structure-Guided Design of Peptide-Based Tryptase Inhibitors
Biochemistry·2006· 25 citedOpen Access
Factor VIIa inhibitors: Improved pharmacokinetic parameters
Bioorganic & Medicinal Chemistry Letters·2006· 13 citedOpen Access
Discovery of novel heterocyclic factor VIIa inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 26 citedOpen Access
bovine trypsin complexed with 2-aminobenzamidazole
2006
Bovine trypsin bound by 4-piperidinebutyrate to make acylenzyme complex
2006
Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model
Bioorganic & Medicinal Chemistry Letters·2006· 30 citedOpen Access
Small molecule inhibitors of plasma kallikrein
Bioorganic & Medicinal Chemistry Letters·2006· 8 citedOpen Access
Factor VIIa inhibitors: Gaining selectivity within the trypsin family
Bioorganic & Medicinal Chemistry Letters·2006· 17 citedOpen Access
Expression, Crystallization, and Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein
Journal of Biological Chemistry·2005· 67 citedOpen Access
Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors
2005
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA)
Journal of Molecular Biology·2004· 37 citedOpen Access
Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure·2004· 691 citedOpen Access
Crystal Structure of Human HDAC8 complexed with MS-344
2004· 1 cited
The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Structure·2003· 85 citedOpen Access
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
Journal of Molecular Biology·2003· 37 citedOpen Access
Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors
Journal of the American Chemical Society·2002· 21 cited
4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
Bioorganic & Medicinal Chemistry Letters·2002· 24 citedOpen Access
2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
Bioorganic & Medicinal Chemistry Letters·2002· 33 citedOpen Access
Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets
Chemistry & Biology·2001· 67 citedOpen Access
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Frequent Co-authors

Paul A. Sprengeler(19), Christine Luong(15), William D. Shrader(11), Wendy B. Young(11), Richard L. Mackman(11), James W. Janc(10), Erik Verner(9), Kyle Elrod(9), Jeffrey R. Spencer(8), Roopa Rai(8), Beishan Liu(6), Darin A. Allen(6), Aleksandr Kolesnikov(6), Hon C. Hui(5), Mary E. McGrath(5), Huiyong Hu(5), John R. Somoza(4), Joseph D. Ho(4), Arnold Martelli(4), J. Guy Breitenbucher(4)