Leire Casas-Fraile

KU Leuven — Belgium

Medicine · Health Sciences

6h-index208citations11works0.02yr avg
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Research Topics

Osteoarthritis Treatment and Mechanisms(5), Muscle Physiology and Disorders(5), Cancer-related molecular mechanisms research(4), Genetic Neurodegenerative Diseases(3), Cancer-related gene regulation(3)

Publications11 total

THE HOMEOSTATIC HYPOXIC ENVIRONMENT IN ARTICULAR CARTILAGE SUSTAINS DOT1L ACTIVITY AND H3K79 METHYLATION TO PROTECT AGAINST OSTEOARTHRITIS
Osteoarthritis and Cartilage·2022
Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis
JCI Insight·2021· 28 citedOpen Access
Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related
International Journal of Molecular Sciences·2021· 13 citedOpen Access
Hypoxia induces transcription of DOT1L in articular cartilage to protect against osteoarthritis
2021Open Access
Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo
Biomaterials·2021· 82 citedOpen Access
Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels
Orphanet Journal of Rare Diseases·2020· 15 citedOpen Access
Identification of novel modulators of WNT/β-catenin signalling in articular chondrocytes by large scale siRNA screening
Osteoarthritis and Cartilage·2020
Effect of frizzled related protein (FRZB) on muscles: an inverse relationship between FRZB and calpain-3 with potential impact on muscle dystrophy and osteoarthritis
Osteoarthritis and Cartilage·2018· 1 cited
FRZB and melusin, overexpressed in LGMD2A, regulate integrin β1D isoform replacement altering myoblast fusion and the integrin-signalling pathway
Expert Reviews in Molecular Medicine·2017· 12 citedOpen Access
Costamere proteins and their involvement in myopathic processes
Expert Reviews in Molecular Medicine·2015· 52 cited
Entire <i>CAPN3</i> gene deletion in a patient with limb‐girdle muscular dystrophy type 2A
Muscle & Nerve·2014· 5 cited

Frequent Co-authors

Adolfo López de Munaín(6), Amets Sáenz(6), Rik Lories(6), F.M. Cornelis(5), Silvia Monteagudo(4), Oihane Jaka(3), Astrid De Roover(3), Ana Escribano-Núñez(3), C. Cherifi(3), An Sermon(3), F. Cailotto(3), Anabel Rico(3), Domiziana Costamagna(2), Maurilio Sampaolesi(2), Ana Aiastui(2), Margarita Azpitarte(2), Gabriella Nilsson Hall(1), Wai Long Tam(1), Konstantinos S. Andrikopoulos(1), George A. Voyiatzis(1)