Emmanuel Gustin

Janssen (Belgium) — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index860citations43works0.42yr avg
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Research Topics

Cell Image Analysis Techniques(11), Advanced Fluorescence Microscopy Techniques(7), Advanced Chemical Physics Studies(5), Luminescence Properties of Advanced Materials(5), Computational Drug Discovery Methods(5)

Publications43 total

Optimization of the drug-induced cholestasis index based on advanced modeling for predicting liver toxicity
Toxicology·2025· 3 cited
Targeting Druggable Pockets in Dengue Virus Envelope Protein: Insights from Structural Analysis and High-Throughput Screening
SSRN Electronic Journal·2025Open Access
Supplementary Methods from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
Data from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
Supplementary Tables from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
Supplementary Figures from Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity
2024Open Access
P01-23 Optimization of predictive liver toxicity modeling based on the drug-induced cholestasis index
Toxicology Letters·2024
P16-06: High-content imaging of human hepatic spheroids for studying compounds with cholestatic liability
Toxicology Letters·2023
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models
Chemical Research in Toxicology·2023· 20 citedOpen Access
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures
SLAS DISCOVERY·2023· 3 citedOpen Access
REMBI: Recommended Metadata for Biological Images—enabling reuse of microscopy data in biology
Nature Methods·2021· 119 citedOpen Access
Development of a cellular high-content, immunofluorescent HBV core assay to identify novel capsid assembly modulators that induce the formation of aberrant HBV core structures
Journal of Virological Methods·2021· 9 cited
Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines
Scientific Reports·2020· 65 citedOpen Access
Tales of 1,008 Small Molecules: Phenomic Profiling through Live-cell Imaging in a Panel of Reporter Cell Lines
2020· 8 citedOpen Access
Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery
Cell chemical biology·2018· 247 citedOpen Access
Combining multiple cell-line imaging datasets for protein-ligand activity prediction
Faculty of 1000 Research Ltd·2018Open Access
Repurposed high-throughput images enable biological activity prediction for drug discovery
2017· 4 citedOpen Access
Ellipsoid Segmentation Model for Analyzing Light-Attenuated 3D Confocal Image Stacks of Fluorescent Multi-Cellular Spheroids
PLoS ONE·2016· 12 citedOpen Access
A Duplex Real-Time RT-PCR Assay for Profiling Inhibitors of Four Dengue Serotypes
Methods in molecular biology·2013· 7 cited
A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion
Methods in molecular biology·2013
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Frequent Co-authors

D. Schoemaker(17), A. Bouwen(13), M. Leblans(11), Hugo Ceulemans(6), Fritz Lüty(6), Yolanda Chong(5), Steffen Jaensch(5), Bie Verbist(5), Jörg K. Wegner(4), Pieter J. Peeters(4), Dirk Brehmer(4), Lijs Beke(4), Tongfei Wu(4), Hillary J. Millar(4), Christopher Moy(4), Weimei Sun(4), Geert Mannens(4), Vineet Pande(4), An Boeckx(4), Erika van Heerde(4)