James A. Henderson

C4 Therapeutics (United States) — United States

Neuroscience · Life Sciences

27h-index2.3kcitations155works1.72yr avg
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Research Topics

Neural dynamics and brain function(19), Synthetic Organic Chemistry Methods(14), Legal Systems and Judicial Processes(14), Law, Economics, and Judicial Systems(13), Functional Brain Connectivity Studies(11)

Publications154 total

Design, synthesis and biological evaluation of macrocyclic NTRK heterobifunctional degraders
Bioorganic & Medicinal Chemistry Letters·2026
Electrical circuit model of spatiotemporal trade dynamics: Foundations and derivation of the gravity model
PLoS ONE·2025Open Access
Determination of steady state brain KP,UU of BIDAC(TM) degraders using chemical knock out animal models
Drug Metabolism and Pharmacokinetics·2025
Arriving at Reasonable Alternative Design: The Reporters' Travelogue
University of Michigan Journal of Law Reform·2025Open Access
255 - Beyond Sensory: SNM Lead Sensing Consistently Measures Patient-Specific Sacral Evoked Responses
Continence·2024Open Access
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Communications Chemistry·2024· 7 citedOpen Access
Abstract P39: CFT7455, a novel IKZF1/3 degrader enhances the anti-myeloma activity of monoclonal and bispecific antibodies by augmenting immune responses
Blood Cancer Discovery·2024· 5 cited
CFT7455, a novel IKZF1/3 degrader, demonstrates potent activity in peripheral and CNS models of NHL as a single agent or in combination with clinically approved agents
Hematological Oncology·2023· 5 citedOpen Access
CFT7455, a Novel IKZF1/3 Degrader, Demonstrates Potent Anti-Tumor Activity in Models of Non-Hodgkin's Lymphoma As a Single Agent or in Combination with Clinically Approved Agents
Blood·2022· 4 cited
Empirical estimation of the eigenmodes of macroscale cortical dynamics: Reconciling neural field eigenmodes and resting-state networks
Neuroimage Reports·2022· 15 citedOpen Access
Abstract ND13: The discovery and characterization of CFT7455: A potent and selective degrader of IKZF1/3 for the treatment of relapsed/refractory multiple myeloma
Cancer Research·2022· 3 cited
Generalized neural field theory of cortical plasticity illustrated by an application to the linear phase of ocular dominance column formation in primary visual cortex
Biological Cybernetics·2021
Determination of Dynamic Brain Connectivity via Spectral Analysis
Frontiers in Human Neuroscience·2021· 23 citedOpen Access
Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models
Cancer Research·2021· 7 cited
CFT7455: A NOVEL, IKZF1/3 DEGRADER THAT DEMONSTRATES POTENT TUMOR REGRESSION IN A SPECTRUM OF NHL XENOGRAFT MODELS
Hematological Oncology·2021· 5 cited
Brain dynamics and structure-function relationships via spectral factorization and the transfer function
NeuroImage·2021· 10 citedOpen Access
Development of an AchillesTAG degradation system and its application to control CAR-T activity
Current Research in Chemical Biology·2021· 20 citedOpen Access
Commentary on “The growth of cognition: Free energy minimization and the embryogenesis of cortical computation”
Physics of Life Reviews·2020· 1 cited
Civil Liability for Encouraging Bad Behavior: From Cheering at a Gang Rape to Promoting Opioid Abuse
UF Law Scholarship Repository (University of Florida)·2019Open Access
Functional mechanisms underlie the emergence of a diverse range of plasticity phenomena
PLoS Computational Biology·2018· 5 citedOpen Access
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Frequent Co-authors

Andrew J. Phillips(10), P. A. Robinson(8), Katrina L. Jackson(6), Somwrita Sarkar(4), Hajime Motoyoshi(3), David E. Heinrichs(3), Doreen E. Culham(3), Janet M. Wood(3), Yoshito Kishi(3), Jinwang Xu(3), Kevin Aquino(3), Aaron D. Twerski(3), Eric D. Brown(2), Anh Ly(2), Theodore Eisenberg(2), Peter A. Robinson(2), Simon Giroux(2), T. Jagadeeswar Reddy(2), Mark R. Morris(2), Kevin M. Cottrell(2)