Simon Giroux

Vertex Pharmaceuticals (United States) — United States

Chemistry · Physical Sciences

13h-index732citations32works4.02yr avg
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Research Topics

Synthetic Organic Chemistry Methods(9), Hepatitis C virus research(5), HIV/AIDS drug development and treatment(5), Asymmetric Synthesis and Catalysis(4), Chemical Synthesis and Analysis(4)

Publications32 total

Palladium‐Catalyzed Hydrodefluorination of Fluoroarenes
Organic Syntheses·2025
Small molecules restore mutant mitochondrial DNA polymerase activity
Nature·2025· 8 citedOpen Access
Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors
ACS Medicinal Chemistry Letters·2021· 13 citedOpen Access
Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors
ACS Medicinal Chemistry Letters·2020· 13 citedOpen Access
ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors
Bioorganic & Medicinal Chemistry Letters·2020· 10 citedOpen Access
Application of a Dual Catalytic Nickel/Iridium-Based Photoredox Reaction to Synthesize 2-Alkyl-<i>N</i>-Arylindoles in a Continuous Flow
The Journal of Organic Chemistry·2020· 3 cited
Palladium Catalyzed Hydrodefluorination of Fluoro-(hetero)arenes
Organic Letters·2019· 33 cited
C–H Functionalization of Heteroarenes Using Unactivated Alkyl Halides through Visible-Light Photoredox Catalysis under Basic Conditions
The Journal of Organic Chemistry·2018· 46 cited
Selenium(IV) Oxide
Encyclopedia of Reagents for Organic Synthesis·2017· 3 cited
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers
Bioorganic & Medicinal Chemistry Letters·2014· 5 cited
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b
Bioorganic & Medicinal Chemistry Letters·2014· 4 citedOpen Access
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores
Bioorganic & Medicinal Chemistry Letters·2014· 13 cited
Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency
Bioorganic & Medicinal Chemistry Letters·2014· 8 citedOpen Access
Design and Strategy in Organic Synthesis: From the Chiron Approach to Catalysis
2013· 40 citedOpen Access
Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors
ACS Medicinal Chemistry Letters·2013· 14 cited
Overcoming acquired resistance to kinase inhibition: The cases of EGFR, ALK and BRAF
Bioorganic & Medicinal Chemistry Letters·2012· 30 citedOpen Access
A Study of the Epoxidation of Cycloolefins by the <i>t</i>-BuOH Copper−Permanganate System
Organic Letters·2009· 12 cited
Enantioselective Synthesis of a Simple Benzenoid Analogue of Glycinoeclepin A
Organic Letters·2008· 7 cited
Syntheses and Biological Evaluation of B-Ring-Modified Analogues of Dafachronic Acid A
Organic Letters·2008· 11 citedOpen Access
An Efficient, Stereocontrolled Synthesis of the 25-(<i>R</i>)-Diastereomer of Dafachronic Acid A from β-Ergosterol
Organic Letters·2008· 29 cited
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Frequent Co-authors

Stephen Hanessian(9), E. J. Corey(6), Kevin M. Cottrell(6), Jinwang Xu(5), T. Jagadeeswar Reddy(5), Mark R. Morris(5), Caroline Cadilhac(5), James A. Henderson(5), Darius Bilimoria(5), François Denis(5), Nagraj Mani(5), Nigel Ewing(5), Rebecca S. Shawgo(5), Lucille L’Heureux(5), Subajini Selliah(5), Laval Chan(5), Nathalie Chauret(5), Françoise Berlioz-Seux(5), Anne‐Laure Grillot(5), Youssef L. Bennani(5)