Giampiero Spalluto

University of Trieste — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index7.1kcitations256works1.02yr avg
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Research Topics

Adenosine and Purinergic Signaling(106), Synthesis and Biological Evaluation(71), Receptor Mechanisms and Signaling(59), Synthesis and Characterization of Heterocyclic Compounds(36), Pharmacological Receptor Mechanisms and Effects(34)

Publications256 total

Adenosine Receptors in Neuroinflammation and Neurodegeneration
Cells·2025· 1 citedOpen Access
7-Amino-[1,2,4]triazolo[1,5-a][1,3,5]triazines as CK1δ inhibitors: Exploring substitutions at the 2 and 5-positions
Bioorganic Chemistry·2024· 1 citedOpen Access
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta
Pharmaceuticals·2024Open Access
Adenine derivatives as inhibitors of the casein kinase CK1delta enzyme
Medicinal Chemistry Research·2024· 1 citedOpen Access
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective
ChemMedChem·2024· 2 citedOpen Access
Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors
Biomolecules·2023Open Access
[1,2,4]Triazolo[1,5‐<i>c</i>]pyrimidines as Tools to Investigate A<sub>3</sub> Adenosine Receptors in Cancer Cell Lines
ChemMedChem·2023· 2 cited
Front Cover: Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors (ChemMedChem 14/2023)
ChemMedChem·2023Open Access
Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors
ChemMedChem·2023· 3 citedOpen Access
“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
Pharmaceuticals·2023· 13 citedOpen Access
Adenosine Receptor Ligands, Probes, and Functional Conjugates: A 20-Year History of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidines (PTP)
Topics in medicinal chemistry·2023
Riluzole–Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis
ACS Chemical Neuroscience·2022· 14 citedOpen Access
The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?
International Journal of Molecular Sciences·2022· 21 citedOpen Access
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases
Current Medicinal Chemistry·2022· 44 citedOpen Access
A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ
International Journal of Molecular Sciences·2021· 20 citedOpen Access
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems
European Journal of Medicinal Chemistry·2021· 17 citedOpen Access
Potent and selective A<sub>3</sub> adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties
RSC Medicinal Chemistry·2020Open Access
Targeting G Protein‐Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A<sub>3</sub> Adenosine Receptor
ChemMedChem·2020· 7 citedOpen Access
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 δ Inhibitors
ACS Medicinal Chemistry Letters·2020· 16 citedOpen Access
Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes
European Journal of Medicinal Chemistry·2019· 14 citedOpen Access
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Frequent Co-authors

Barbara Cacciari(26), Pier Giovanni Baraldi(19), Stefano Moro(18), Tatiana Da Ros(12), Pier Andrea Borea(12), Maurizio Prato(11), Katia Varani(11), Romeo Romagnoli(10), Giorgia Pastorin(10), Stefania Gessi(7), Karl‐Norbert Klotz(7), Stephanie Federico(7), Kenneth A. Jacobson(6), Stefania Merighi(5), Susanna Bosi(4), Ennio Ongini(4), Francesca Deflorian(4), Siew Lee Cheong(4), Angela Monopoli(3), Silvio Dionisotti(3)