Charles A. Dinarello

Radboud University Nijmegen — Netherlands

Immunology and Microbiology · Life Sciences

196h-index144.3kcitations1.2kworks4.32yr avg
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Research Topics

Immune Response and Inflammation(283), Inflammasome and immune disorders(250), Immune Cell Function and Interaction(164), Cytokine Signaling Pathways and Interactions(104), IL-33, ST2, and ILC Pathways(97)

Publications1.2k total

IL-1 family of cytokines in gastrointestinal and liver disorders
Nature Reviews Gastroenterology & Hepatology·2025
Pharmacologic NLRP3 Inhibition Modulates Parkinson’s Disease-Associated Microglial Transcriptomic Signatures and Mitigates α-Synuclein–Triggered Neurodegeneration
2025· 1 cited
Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study
iScience·2025Open Access
A Functional Polymorphism in IL-36β Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis
The Journal of Infectious Diseases·2025· 3 cited
Micro- and nano-plastics induce inflammation and cell death in human cells
Frontiers in Immunology·2025· 10 citedOpen Access
Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease
Frontiers in Immunology·2025· 1 citedOpen Access
Abstract 4115645: NLRP3 Inflammasome Inhibition With Dapansutrile in Type 2 Diabetes and Elevated Systemic Inflammation: Rationale and Design of the DAPAN-DIA study
Circulation·2024Open Access
Inflammation Promotes Aging‐Associated Oncogenesis in the Lung
Aging and Cancer·2024· 2 citedOpen Access
IL-1 receptor antagonism reveals a yin-yang relationship between NFκB and interferon signaling in chronic lymphocytic leukemia
Proceedings of the National Academy of Sciences·2024· 2 citedOpen Access
Screening NLRP3 drug candidates in clinical development: lessons from existing and emerging technologies
Frontiers in Immunology·2024· 17 citedOpen Access
An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation
Frontiers in Immunology·2024· 3 citedOpen Access
Su1742 INTERLEUKIN-1 RECEPTOR 9 GENE DELETION WORSENS MURINE COLITIS
Gastroenterology·2024
Alpha1-antitrypsin impacts innate host–pathogen interactions with <i>Candida albicans</i> by stimulating fungal filamentation
Virulence·2024· 8 citedOpen Access
International nomenclature guidelines for the IL-1 family of cytokines and receptors
Nature Immunology·2024· 11 cited
Inflammation promotes aging-associated oncogenesis in the lung
2024· 5 citedOpen Access
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application
Immune Network·2024· 5 citedOpen Access
Metabolic reprogramming of the inflammatory response in the nervous system: the crossover between inflammation and metabolism
Neural Regeneration Research·2023· 11 citedOpen Access
Metabolic Alterations Associated with Loss of TET2 Potentiates Inflammation in Myeloid Cells Driving Breast Cancer Progression
Blood·2023· 1 citedOpen Access
IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion
Proceedings of the National Academy of Sciences·2023· 6 citedOpen Access
NLRP3 and cancer: Pathogenesis and therapeutic opportunities
Pharmacology & Therapeutics·2023· 36 citedOpen Access
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Frequent Co-authors

Leo A. B. Joosten(5), Jos W.M. van der Meer(4), Frank L. van de Veerdonk(4), Mihai G. Netea(4), Alberto Mantovani(3), Ronenn Roubenoff(3), Michael T. Heneka(2), Eicke Latz(2), Douglas T. Golenbock(2), Stefan Endres(2), J.W.M. van der Meer(2), Joseph G. Cannon(2), Sheldon Wolff(2), Cecília Garlanda(2), Kirk R. Manogue(2), Franklin H. Epstein(2), Elena Voronov(2), Ron N. Apte(2), Daniela Novick(2), Marcel F. Nold(2)